Metabolism following function or function following metabolism: a study of AMPK in tumor-associated macrophages KU Leuven
Tumor-associated macrophages (TAMs) are the orchestrators of the inflammatory response in tumors. TAMs exist as a phenotypic spectrum ranging from tumoricidal M1-like macrophages (MOs) to pro-tumoral M2-like MOs. It is becoming clear that MOs alter their metabolism to meet the energetic requirements imposed by their functional polarization, but these processes are ill defined. MO heterogeneity reflects the plasticity and versatility of these ...