Projects
Effect of metabolic gas transport on the central metabolism of pear fruit (Pyrus communis L.): a computational biologoy approach. KU Leuven
Division of Mechatronics, Biostatistics and Sensors (MeBioS), Mechatronics, Biostatistics and Sensors (MeBioS)
After harvest, apple (Malus x domestica Borkh.) fruit remains metabolically active and continues to ripen. The main goal of postharvest storage is to slow down this metabolic activity and its associated fruit ripening. Therefore, large volumes of apple fruit are routinely stored under controlled atmosphere (CA) conditions (low temperature, low oxygen and high carbon dioxide partial pressures) with recent developments moving ...
Joining forces: Leveraging large metabolite and enzymatic PhD datasets (KU Leuven) in a computational systems biology approach (Oxford University) to increase our insights into the metabolic network of CAM plants KU Leuven
ECOOM - Centre for Research and Development Monitoring, Crop Biotechnics, Declarative Languages and Artificial Intelligence (DTAI)
In this research, forces of KU Leuven and Oxford University are joined to increase our insights into the metabolic network of plants with Crassulacean Acid Metabolism (CAM). The research group of Prof. Sweetlove (Oxford University) recently developed a multi-phase model for CAM by computational modelling. This model can account for the dynamics in metabolites during the cycle at a 2h time resolution but has many degrees of freedom which results ...
Glutathiontransport and - metabolism in bacteria and evaluation of a disruption of the cofactordieet the central metabolism of yeast. Ghent University
Dynamics in the Central Plant Cell Metabolism KU Leuven
Laboratory of Protein Phosphorylation and Proteomics, Division of Mechatronics, Biostatistics and Sensors (MeBioS)
As part of their development, plants have acquired adaptive mechanisms to cope with different stress situations they encounter in their environment. These adaptive mechanisms include the ability to alter their metabolism when faced with extreme environmental conditions such as low oxygen. In higher plants, oxygen (O2) availability is important for energy production through respiratory metabolism. Under conditions where O2 becomes limiting, ...
Characterization of occurrence, metabolism and contribution to human exposure of new chemicals present in the indoor environment. University of Antwerp
Chemicals are typically used in various products because of their beneficial properties, e.g. flame retardants, plasticizers, etc. However, most of them leach into the indoor environment and may provoke health disorders (e.g. endocrine disruption). With this proposal, we aim to enrich the fundamental knowledge related to new chemicals of concern by studying their occurrence in the indoor environment. Furthermore, we will characterize their ...
Micrometabolite/Isolation and functional characterization of root endophytic bacteria from Boraginaceae that promote growth and affect plant secondary metabolism. Ghent University
Plant-derived natural products or, more specifically, plant secondary metabolites are backbones of today’s pharmaceutical and cosmeceutical industry. Plant-associated microorganisms have been implicated an important role in sustaining plant growth and, through inducing or influencing synthesis pathways, in the production of plant secondary metabolites. MICROMETABOLITE aims at exploring the plant-associated microflora for improving the ...
Genomic and functional molecular characterization of root endophytic bacteria from Boraginaceae that promote growth and affect plant secondary metabolism. Ghent University
Plant-derived natural products or, more specifically, plant secondary metabolites are backbones of todayU+2019s pharmaceutical and cosmeceutical industry. Plant-associated microorganisms have been implicated an important role in sustaining plant growth and, through inducing or influencing synthesis pathways, in the production of plant secondary metabolites. MICROMETABOLITE aims at exploring the plant-associated microflora for improving the ...
IPSC-HEPs: hepatotoxicity and drug metabolism by biotech and pharmaceutical companies. KU Leuven
As a result of several finalized projects we developed a robust differentiation protocol for the generation of hepatic progeny from induced pluripotent stem cells (iPSCs) with drug metabolisation enzyme function in the 30 percent range of primary plated (12h) hepatocytes. Furthermore we can now maintain these cells for =/> 2 weeks, allowing for the first time repeated dose metabolisation and toxicity studies. We also developed a robust 384 ...
UPLC for simultaneous measurement of primary and secondary metabolites involved in the source-sink metabolism of plants Ghent University
The research group (BW02) has a well-established expertise in the analysis of primary metabolites involved in source-sink relations of crops. Determination of carbohydrates is of crucial importance when studying these processes. We want to extend our expertise as well to other metabolites involved in source-sink relations. Therefore the research group submits a request for a modular UPLC-H.