Effect of metabolic gas transport on the central metabolism of pear fruit (Pyrus communis L.): a computational biologoy approach. KU Leuven
After harvest, apple (Malus x domestica Borkh.) fruit remains metabolically active and continues to ripen. The main goal of postharvest storage is to slow down this metabolic activity and its associated fruit ripening. Therefore, large volumes of apple fruit are routinely stored under controlled atmosphere (CA) conditions (low temperature, low oxygen and high carbon dioxide partial pressures) with recent developments moving ...
Metabolic Profiling of bioactive Antimicrobial Metabolites from Some of the selected Tanzanian Medicinal Plants: Bio-guided fractionation and Untargeted Metabolomics approaches. KU Leuven
Infectious diseases have long been among the main causes of morbidity and mortality in the general population worldwide, and are more prevalent in developing countries. The presence of antimicrobial resistance strains to current available effective antibiotics threatens efforts to eradicate microbial infections. There is an urgent need for the discovery and development of new antimicrobial drugs to cope with the need and avoid running out of ...
Functional characterization of NIC: a new player in the phenylpropanoid metabolic network Ghent University
The plant phenylpropanoid pathway leads to many phenolic metabolites which are crucial for plant growth and development. Although the key enzymes of the pathway are identified, the integration of the pathway in the broader metabolic network is far from understood. In this project we will characterize a previously identified novel interactor of C4H, the second enzyme of the pathway.
The effect of different types of exercise on fecal microbiome, fecal metabolome and metabolic fingerprint of skeletal muscle in the equine athlete. Ghent University
Exercise training effects on gut microbiome and on muscle metabolic status play a pivotal role in performance management in equine athletes. In the current research proposal the differential effect of training types on the equine microbiome and muscle metabolomic profile is studied using 16S rRNA high throughput sequencing of the microbiome and muscle and fecal metabolomic fingerprinting as broad exploration techniques
Metabolic Characterization and Engineering of Streptomyces lividans Producing Heterologous Proteins KU Leuven
Endocrine-disrupting environmental chemicals: From accumulation to their role in the global "neuro-endocrine" epidemic of obesity and its metabolic consequences. University of Antwerp
Metabolic fingerprinting towards diagnosis and prognosis of cow's milk allergy in children. Ghent University
Given the emerging evidence for the involvement of the gut microbiome in the onset of food allergy
and its resolution, this project will rely on our metabolomics platform and microbial analysis of CMA patients' biofluids, for identifying prognostic biomarkers. Specific bacterial groups involved in the biomarker formation, will be manipulated or administered to mice to aid in biomarker qualification.
The main objective of this innovative research is to characterize U+2018metabolic phenotypesU+2019, by means of a high resolution full scan Orbitrap mass spectrometer, which will analyse feces, intact biopsies or exfoliated colonocytes. At a later stage of the research these metabolomic fingerprints may serve as a specific statistically founded prediagnostic screening tool for different types of gastrointestinal disorders (inflammatory bowel ...