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Joining forces: Leveraging large metabolite and enzymatic PhD datasets (KU Leuven) in a computational systems biology approach (Oxford University) to increase our insights into the metabolic network of CAM plants KU Leuven

Johan Ceusters
Crop Biotechnics, Declarative Languages and Artificial Intelligence (DTAI)
In this research, forces of KU Leuven and Oxford University are joined to increase our insights into the metabolic network of plants with Crassulacean Acid Metabolism (CAM). The research group of Prof. Sweetlove (Oxford University) recently developed a multi-phase model for CAM by computational modelling. This model can account for the dynamics in metabolites during the cycle at a 2h time resolution but has many degrees of freedom which results ...

Effect of metabolic gas transport on the central metabolism of pear fruit (Pyrus communis L.): a computational biologoy approach. KU Leuven

Bart Nicolai
Division of Mechatronics, Biostatistics and Sensors (MeBioS), Mechatronics, Biostatistics and Sensors (MeBioS)

After harvest, apple (Malus x domestica Borkh.) fruit remains metabolically active and continues to ripen. The main goal of postharvest storage is to slow down this metabolic activity and its associated fruit ripening. Therefore, large volumes of apple fruit are routinely stored under controlled atmosphere (CA) conditions (low temperature, low oxygen and high carbon dioxide partial pressures) with recent developments moving ...

Metabolic Profiling of bioactive Antimicrobial Metabolites from Some of the selected Tanzanian Medicinal Plants: Bio-guided fractionation and Untargeted Metabolomics approaches. KU Leuven

Joleen Masschelein
Molecular Biotechnology of Plants and Micro-organisms

Infectious diseases have long been among the main causes of morbidity and mortality in the general population worldwide, and are more prevalent in developing countries. The presence of antimicrobial resistance strains to current available effective antibiotics threatens efforts to eradicate microbial infections. There is an urgent need for the discovery and development of new antimicrobial drugs to cope with the need and avoid running out of ...

Functional characterization of NIC: a new player in the phenylpropanoid metabolic network Ghent University

Bartel Vanholme
Department of Plant Biotechnology and Bioinformatics

The plant phenylpropanoid pathway leads to many phenolic metabolites which are crucial for plant growth and development. Although the key enzymes of the pathway are identified, the integration of the pathway in the broader metabolic network is far from understood. In this project we will characterize a previously identified novel interactor of C4H, the second enzyme of the pathway.

The effect of different types of exercise on fecal microbiome, fecal metabolome and metabolic fingerprint of skeletal muscle in the equine athlete. Ghent University

Catherine Delesalle
Department of Translational Physiology, Infectiology and Public Health, Department of Comparative physiology and biometrics

Exercise training effects on gut microbiome and on muscle metabolic status play a pivotal role in performance management in equine athletes. In the current research proposal the differential effect of training types on the equine microbiome and muscle metabolomic profile is studied using 16S rRNA high throughput sequencing of the microbiome and muscle and fecal metabolomic fingerprinting as broad exploration techniques

Metabolic Characterization and Engineering of Streptomyces lividans Producing Heterologous Proteins KU Leuven

Jan Van Impe
Department of Chemical Engineering (CIT), Sustainable Chemical Process Technology, Ghent and Aalst Technology Campuses, Bio- & Chemical Systems Technology, Reactor Engineering and Safety Section, Laboratory of Molecular Bacteriology (Rega Institute)
Streptomycetes have become attractive hosts for heterologous protein production due to for instance, their ability to efficiently secrete theirproteins in the extracellular environment. Among these microbes, Streptomyces lividans</>, known to have a reduced restriction-modification barrier, has been used more extensively for heterologous protein production. Hitherto, studies on metabolic characterization and engineering of S. ...

Endocrine-disrupting environmental chemicals: From accumulation to their role in the global "neuro-endocrine" epidemic of obesity and its metabolic consequences. University of Antwerp

Philippe Jorens
Medical genetics of obesity and skeletal disorders (MGENOS), Systemic Physiological and Ecotoxicological Research (SPHERE), Laboratory Experimental Medicine and Pediatrics (LEMP)
It is recently hypothesised that the disturbance of weight homeostasis leading to obesity in humans might at least partially be influenced by endocrine disrupting chemicals. This study particularly investigates the accumulation and role of older and new emerging endocrine disrupting chemicals in the pandemic of the 21st century called obesity. The effects are studied at molecular, cellular and organism level using in vitro and in vivo ...

Metabolic fingerprinting towards diagnosis and prognosis of cow's milk allergy in children. Ghent University

Department of Translational Physiology, Infectiology and Public Health, Department of Biotechnology, Department of Biomolecular Medicine, Department of Internal Medicine and Pediatrics

Given the emerging evidence for the involvement of the gut microbiome in the onset of food allergy
and its resolution, this project will rely on our metabolomics platform and microbial analysis of CMA patients' biofluids, for identifying prognostic biomarkers. Specific bacterial groups involved in the biomarker formation, will be manipulated or administered to mice to aid in biomarker qualification.

Metabolic fingerprinting of the human gut phenotype in health and disease Ghent University

Department of Veterinary Public Health and Food Safety

The main objective of this innovative research is to characterize U+2018metabolic phenotypesU+2019, by means of a high resolution full scan Orbitrap mass spectrometer, which will analyse feces, intact biopsies or exfoliated colonocytes. At a later stage of the research these metabolomic fingerprints may serve as a specific statistically founded prediagnostic screening tool for different types of gastrointestinal disorders (inflammatory bowel ...