Projects
Identification of causal mutations in patients with unexplained mental retardation and congenital abnormalities by high throughput sequencing of selected candidate genes Ghent University
Chromosomal aberrations as well as pointmutations are an important cause of mental retardation and multipele congenital abnormalities (MR/MCA). In this project, the newest technologies in human genetics (selective resequencing) will be used to resequence 3000 candidate genes for MR/MCA in order to understand the underlying cause of MR/MCA and to gain insights in normal human embryogenesis.
Exome sequencing to identify novel mental retardation genes. University of Antwerp
Array comparative genomic hybridization (array CGH) study of submicroscopic genomic rearrangements in patients with unexplained mental retardation. Ghent University
Identification of novel genes involved in malformations of cortical development (MCD) Ghent University
Malformations of cortical development (MCD) are an important cause of mental retardation. Thus far, only a couple of genes are known to be involved in MCD. In this project we will use a genome wide approach to sequence candidate genes involved in MCD in combination with migration assays for functional analysis in order to elucidate the pathways involved in neuronal migration.
Detection of copy number changes in epilepsy patients using SNP arrays. University of Antwerp
The role of the AnkyrinG interactome in neurodevelopmental disorders. University of Antwerp
Nuclear receptor-based molecular mechanisms in the fight against inflammation and cancer Ghent University
Glucocorticoids (GCs) remain a gold standard in the treatment of chronic inflammatory diseases and
cancer because they can efficiently relieve the inflammation-associated symptoms and kill off immune cells.
However, upon chronic exogenous GC treatment not only the associated side effects, such as diabetes and
osteoporosis, but also the development of therapy resistance, remain cumbersome. Clinical progress ...