Projects
Identification of new dynamic changes associated with mental retardation. University of Antwerp
Functional relevance of epigenetics in mental retardation. KU Leuven
Identification of new dynamic changes associated with mental retardation. University of Antwerp
A genomic approach for the identification of genes involved in mental retardation and brain anomalies. KU Leuven
Detection of novel genome disorders in mental retardation. University of Antwerp
The Fragile X Mental Retardation Protein FMRP controls the earliest steps of epithelial-mesenchymal transition, an important bottleneck in the progression of cancer towards metastasis formation. KU Leuven
The major cause of cancer-related deaths are the metastases, not the primary tumours. To successfully form a metastasis, a cancer cell has to go through several limiting steps, and the earlier the process can be stopped the better. The first step in the formation of metastases - which therefore would be the best point of pharmaceutical intervention - is the so-called epithelial to mesenchymal transition (‘EMT’). In this process, the cell ...
Molecular and biochemical insights of the Fragile X Mental Retardation Protein: effects on tumour progression and metastasis formation. KU Leuven
Functional relevance of epigenetic changes in mental retardation. KU Leuven
Identification of causal mutations in patients with unexplained mental retardation and congenital abnormalities by high throughput sequencing of selected candidate genes Ghent University
Chromosomal aberrations as well as pointmutations are an important cause of mental retardation and multipele congenital abnormalities (MR/MCA). In this project, the newest technologies in human genetics (selective resequencing) will be used to resequence 3000 candidate genes for MR/MCA in order to understand the underlying cause of MR/MCA and to gain insights in normal human embryogenesis.