Projects
MaTIAS - Machine Translation to Inform Asylum Seekers Ghent University
Materials' Innovations for a Safe and Sustainable nuclear in Europe. KU Leuven
The European Energy Research Alliance, set-up under the European Strategic Energy Technology Plan, has launched an initiative for a Joint Programme on Nuclear Materials (JPNM). The JPNM aims at establishing key priorities in the area of advanced nuclear materials, identifying funding opportunities and harmonizing this scientific & technical domain at the European level by maximizing complementarities and synergies with the major actors of ...
Advanced Infrared Interferometry Techniques for Exoplanets Characterization (AIITEC) KU Leuven
The study of exoplanets is one of the big drivers of astrophysics and space missions today, as these worlds orbiting distant stars can reveal much about the origin of our own solar system, and the presence of life in the universe. Over 5000 exoplanets have been detected so far by using indirect methods. Only a handful have been detected directly to be studied in spectroscopy because current instruments only allow us to detect the very young, ...
Oral drug absorption in specific patient populations: understanding the impact of gastrointestinal physiology KU Leuven
Oral drug administration is the most commonly used route of drug administration. Oral drug absorption-related processes, including, solubility, dissolution, permeation and metabolism, are highly dependent on the gastrointestinal (GI) physiology. Hence, the success of an oral drug formulation can be affected by an altered GI physiology. Several factors have been hypothesized to affect GI physiology, including age, GI diseases (e.g., ulcerative ...
Characterizing the esophageal function of infants in the NICU. KU Leuven
Infants admitted in the neonatal unit commonly present with feeding problems such as decreased oral intake and feeding intolerance. These infants may suffer from complex diseases such as prematurity or congenital malformations. The origin of these feeding problems may be disease-specific or may be secondary to many factors such as severity of the illness, concomitant medication and surgical interventions.
“Healthy” preterm ...
Study on the impact of Nlrp3 inflammasome activation in intra-epithelial lymphocytes on intestinal inflammation Ghent University
The Nlrp3 inflammasome is a protein complex responsible for mounting cytokine and cell death responses upon detecting microbial or host-derived stress signals. Nlrp3 variants are associated with Crohn’s Disease (CD) but the cellular origins of these detrimental Nlrp3 signaling effects have not been identified. While Nlrp3 is thought to be expressed only in innate immune cells I have data showing that also small intestinal intra-epithelial ...
Investigating the effects of regulatory phosphorylation and linear ubiquitination on Pyrin-mediated auto-inflammatory disorders. Ghent University
Enhanced inflammasome signaling due to Pyrin mutations underlie auto-inflammation in Familial Mediterranean Fever (FMF). We obtained evidence that also Otulin-related auto-inflammatory syndrome (ORAS) involves enhanced Pyrin signaling. In this project, we will investigate the mechanisms by which Pyrin signaling is regulated by phosphorylation and linear ubiquitination, and how this modulates Pyrin-mediated auto-inflammation in FMF and ORAS ...
Evaluating the function and the therapeutic potential of IFN-λ in intestinal carcinogenesis Ghent University
Colorectal cancer is the third most common malignancy and the fourth leading cause of cancerrelated
deaths in the world, and its burden is expected to increase to more than 1,1 million deaths
per year by 2030. Better understanding of the carcinogenesis mechanisms is needed to improve
treatment strategies. Type I interferons (IFNs) exert diverse roles in the immune system and harbour
cytotoxic and anti-proliferative ...