Publications
Crystallisation and preliminary X-ray analysis of two variants of the Escherichia coli O157 PaaA2-ParE2 antitoxin-toxin complex Vrije Universiteit Brussel
Production, crystallisation and X-ray diffraction analysis of two nanobodies against the Duffy Binding like domain DBL6e-FCR3 of the Plasmodium falciparum VAR2CSA protein Vrije Universiteit Brussel
Structure determination of GFP-like proteins KU Leuven
Regulatory mechanisms behind the activities of bacterial HEPN ribonuclease RnlA and ParE2 gyrase poison Vrije Universiteit Brussel
Solid-state structure of cyclic dipeptides : an X-ray and computational study of cis- and trans-diketo-piperazines of N-methyl-phenylalanine with the thia-pipecolic acids and thia-prolines Ghent University
Allosteric nanobodies reveal the dynamic range and diverse mechanisms of G-protein-coupled receptor activation Vrije Universiteit Brussel
G-protein-coupled receptors (GPCRs) modulate many physiological processes by transducing a variety of extracellular cues into intracellular responses. Ligand binding to an extracellular orthosteric pocket propagates conformational change to the receptor cytosolic region to promote binding and activation of downstream signalling effectors such as G proteins and β-arrestins. It is well known that different agonists can share the same binding ...
Functional and Biochemical Characterization of Alvinella pompejana Cys-Loop Receptor Homologues Vrije Universiteit Brussel KU Leuven
Cys-loop receptors are membrane spanning ligand-gated ion channels involved in fast excitatory and inhibitory neurotransmission. Three-dimensional structures of these ion channels, determined by X-ray crystallography or electron microscopy, have revealed valuable information regarding the molecular mechanisms underlying ligand recognition, channel gating and ion conductance. To extend and validate the current insights, we here present ...