Whole genome comparisons suggest random distribution of Mycobacterium ulcerans genotypes in a Buruli ulcer endemic region of Ghana Institute of Tropical Medicine University of Antwerp
Efforts to control the spread of Buruli ulcer--an emerging ulcerative skin infection caused by Mycobacterium ulcerans--have been hampered by our poor understanding of reservoirs and transmission. To help address this issue, we compared whole genomes from 18 clinical M. ulcerans isolates from a 30 km2 region within the Asante Akim North District, Ashanti region, Ghana, with 15 other M. ulcerans isolates from elsewhere in Ghana and the ...
Recent advances in leprosy and Buruli ulcer (Mycobacterium ulcerans infection) Institute of Tropical Medicine
Mycobacterium ulcerans population genomics to inform on the spread of Buruli Ulcer across Central Africa University of Antwerp
Investigating the role of free-living amoebae as a reservoir for Mycobacterium ulcerans Institute of Tropical Medicine University of Antwerp
BACKGROUND: The reservoir and mode of transmission of Mycobacterium ulcerans, the causative agent of Buruli ulcer, still remain a mystery. It has been suggested that M. ulcerans persists with difficulty as a free-living organism due to its natural fragility and inability to withstand exposure to direct sunlight, and thus probably persists within a protective host environment.
METHODOLOGY/PRINCIPAL FINDINGS: We investigated the role of ...
Mycobacterium ulcerans triggers T cell immunity followed by local and regional but not systemic immunosuppression Institute of Tropical Medicine
Persistence of Mycobacterium ulcerans Disease (Buruli Ulcer) in the Historical Focus of Kasongo Territory, the Democratic Republic of Congo KU Leuven Ghent University University of Antwerp Institute of Tropical Medicine
Multiple introductions and recent spread of the emerging human pathogen Mycobacterium ulcerans across Africa Institute of Tropical Medicine University of Antwerp
Buruli ulcer (BU) is an insidious neglected tropical disease. Cases are reported around the world but the rural regions of West and Central Africa are most affected. How BU is transmitted and spreads has remained a mystery, even though the causative agent, Mycobacterium ulcerans, has been known for more than 70 years. Here, using the tools of population genomics, we reconstruct the evolutionary history of M. ulcerans by comparing 165 isolates ...
Insertion sequence element single nucleotide polymorphism typing provides insights into the population structure and evolution of Mycobacterium ulcerans across Africa Institute of Tropical Medicine University of Antwerp
Buruli ulcer is an indolent, slowly progressing necrotizing disease of the skin caused by infection with Mycobacterium ulcerans. In the present study, we applied a redesigned technique to a vast panel of M. ulcerans disease isolates and clinical samples originating from multiple African disease foci in order to (i) gain fundamental insights into the population structure and evolutionary history of the pathogen and (ii) disentangle the ...