Publications
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Synthesis and bioactivity of U+03B2-substituted fosmidomycin analogues targeting 1-deoxy-D-xylulose-5-phosphate reductoisomerase Ghent University University of Antwerp
Inflammasomes in respiratory disease: from bench to bedside Ghent University
Development of U+03B1GlcN(1 <-> 1)U+03B1Man-based Lipid A mimetics as a novel class of potent Toll-like Receptor 4 agonists Ghent University
AhR sensing of bacterial pigments regulates antibacterial defence Ghent University
The aryl hydrocarbon receptor (AhR) is a highly conserved ligand-dependent transcription factor that senses environmental toxins and endogenous ligands, thereby inducing detoxifying enzymes and modulating immune cell differentiation and responses. We hypothesized that AhR evolved to sense not only environmental pollutants but also microbial insults. We characterized bacterial pigmented virulence factors, namely the phenazines from Pseudomonas ...
Division of labor between lung dendritic cells and macrophages in the defense against pulmonary infections Ghent University
The lung is highly exposed to the external environment. For this reason, the lung needs to handle a number of potential threats present in inhaled air such as viruses or bacteria. Dendritic cells (DCs) and macrophages (MFs) play an important role in orchestrating the immune responses to these challenges. The severe lung inflammation caused by some pathogens poses a unique challenge to the immune system: the potential insult must be eliminated ...
Tuberculosis clinical trial update and the current anti-tuberculosis drug portfolio Ghent University
In situ microscopy analysis reveals local innate immune response developed around Brucella infected cells in resistant and susceptible mice Ghent University
Brucella are facultative intracellular bacteria that chronically infect humans and animals causing brucellosis. Brucella are able to invade and replicate in a broad range of cell lines in vitro, however the cells supporting bacterial growth in vivo are largely unknown. In order to identify these, we used a Brucella melitensis strain stably expressing mCherry fluorescent protein to determine the phenotype of infected cells in spleen and liver, ...