Characterization and exploitation of the mycothiol redox system of Mycobacterium tuberculosis Vrije Universiteit Brussel
Consequences of Mycobacterium tuberculosis genetic diversity in the context of HIV co-infection for laboratory diagnosis of tuberculosis in Africa Institute of Tropical Medicine
1. To determine the variation and risk factors for drug-resistant tuberculosis in sub-Saharan Africa.
2. To evaluate the clinical utility of a novel molecular assay in various combinations with existing methods for diagnosis of HIV-related tuberculosis.
3. To determine the clinical predictors of mycobacteremia among HIV-infected smear- negative adults in a high prevalence HIV/TB setting in relation to the utility of ...
Application of enzyme substrate analogues: from inhibitors with anti-mycobacterial properties to synthetic genetic polymers KU Leuven
Tuberculosis (TB) is an infectious disease caused by the bacillus Mycobacterium tuberculosis (M. tuberculosis).It is regarded as the leading cause of death from a single infectious agent, even above HIV/AIDS. Although the global tuberculosis incidence has declined marginally over the past two decades, it still affects 10 million people each year and remains out of control in several parts of Africa ...
Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis. KU Leuven
The prevalence of drug resistance in Mycobacterium tuberculosis (Mtb) calls for the legitimization of new and highly specific drug targets, focusing on unique pathways. The mycothiol ligase (MshC) and mycothione reductase (Mtr) are two components of the mycobacterial redox homeostasis that display the three key components of antibiotic drug targets; high druggability and the potential to show high specificity and essentiality for the ...
Development of a comprehensive platform for targeting redox homeostasis in Mycobacterium tuberculosis. University of Antwerp
Mycobacterium tuberculosis defence mechanisms against aggressive oxygen: signalling and protection against overoxidation Vrije Universiteit Brussel
Laying the foundation for whole genome sequencing of clinical Mycobacterium tuberculosis isolates in the rural Eastern Cape area of South Africa. University of Antwerp
Mycobacterium tuberculosis in a cholesterol and fatty acid rich environment: global response to dormancy and antibiotic resistance Ghent University
Little is still known on the role of lipids in the survival of Mycobacterium tuberculosis. The general objective of this research project is to determine and analyze the global genetic expression of M. tuberculosis and to evaluate its drug susceptibility in an in vitro latency model in the presence of lipids cholesterol and fatty acids.