Projects
Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine KU Leuven
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.
MultipleMS will therefore develop, validate, and exploit ...
Tournesol 2009: project T2009.20: Glycine system ans microglia in normal brain and Multiple Sclerosis Hasselt University
Somatic mutations leading to CD8+T cell proliferation contribute to the pathogenesis of multiple sclerosis KU Leuven
Following on the development and validation of the pipeline and the proof-of-concept in MS (multiple sclerosis), l will now investigate whether and how somatic mutations contribute to the pathogenesis of MS. In particular, l will investigate whether these cells are pathogenic, confer a particular inflammatory or proliferative phenotype, and have the ability to migrate into the CNS. If proven to be pathogenic, they can indicate new targets tor ...
The genetic basis for relapse rate in multiple sclerosis KU Leuven
In this project we investigate what causes relapse in MS (multiple sclerosis). This insight would provide new targets for treatments and tools for prognosis.
The immunogenetic architecture of disease heterogeneity in multiple sclerosis KU Leuven
Multiple sclerosis (MS) is one of the most common neurological disorders in young adults, affecting around 10,000 people in Belgium and leading to important physical as well as cognitive disability. MS is characterized by three hallmarks: inflammation, demyelination and axonal loss. More than 200 genetic risk factors for MS have been identified. These genetic risk factors indicate a primary role for the immune system in MS, and have ...
Somatic mutations leading to CD8+ T cell proliferation contribute to the pathogenesis of multiple sclerosis KU Leuven
Multiple sclerosis (MS) is one of the most common neurological disorders in young adults, affecting around 10,000 people in Belgium and leading to important physical as well as cognitive disability. MS is characterized by three hallmarks: inflammation, demyelination and neuronal loss. During our previous FWO project, we identified >200 genetic factors for susceptibility to MS as well as a different set of genetic factors explaining ...
Study of the role of NF-kB regulatory signalling molecules involved in multiple sclerosis through gene targeting in the mouse Ghent University
In this project we investigate the role of NF-kB in multiple sclerosis. Therefore we make use of knockout mice that are deficient in specific NF-kB regulatory genes, and we use these mice in models of multiple sclerose. In this way we hope to better understand the function of specific genes in multiple sclerosis.