Projects
Elucidating the role of Epstein-Barr virus in multiple sclerosis pathophysiology. KU Leuven
Multiple sclerosis (MS) is one of the most common neurological disorders in young adults, affecting around 13,500 people in Belgium and 2.5 million worldwide. The disease can lead to important physical as well as cognitive disability at a time that is crucial in the personal and professional development of patients. Belgium constitutes a relatively high-prevalence country in which MS continues to pose a major personal and socio-economic ...
Deep immune-phenotyping of multiple sclerosis patients using advanced spectral flow cytometry Hasselt University
MACSiMiSE-BRAIN: Metformin Add-on Clinical Study in Multiple Sclerosis to Evaluate Brain Remyelination And Neurodegeneration Hasselt University
Using machine learning to model the prognosis of multiple sclerosis patients KU Leuven
Multiple sclerosis is a complex disease with a highly heterogeneous disease course. In this project, we will develop machine learning methods to study this disease course using a combination of demographical, clinical, genomic, and radiomic data. This study is done on the patient level (individualized prognosis models), on the group level (patient stratification models), and on the population level (identification of prognostic biomarkers). ...
Investigating precision in predictive coding during walking to music and metronomes in progressive multiple sclerosis and cerebellar disease. Hasselt University
Inter-individual variation in susceptibility to and disease course of multiple sclerosis KU Leuven
Multiple sclerosis (MS) is a common neuroinflammatory disorder. MS typically affects young adults and can lead to important physical and cognitive disability at a crucial stage in their life. There are approximately 13,500 individuals suffering from the disease in Belgium, and 2.5 million worldwide. Characteristics of the disease are inflammation, demyelination and axonal loss in brain and spinal cord. In collaboration with colleagues ...
Biomarkers of multiple sclerosis disease course in the blood and in the gut KU Leuven
Multiple sclerosis (MS) is an inflammatory, degenerative disease of the central nervous system with a heterogeneous disease course. Previous studies indicate a role of the gut microbial community (microbiota) in the pathogenesis of MS. However, a lot remains unclear as most studies with MS patients were relatively small-scale, cross-sectional and considering few possible confounders. There is a need for large prospective studies of the gut ...
Associations of the gut microbiota with inflammatory disease activity in multiple sclerosis KU Leuven
Multiple sclerosis (MS) is a chronic inflammatory and neurodegenerative disease of the central nervous system characterized by a wide clinical heterogeneity. Recent advances indicate a role for the gut microbial community, the so-called gut microbiota, in MS. Via the gut-brain axis, a bidirectional communication system involving immune, neural, metabolic, and endocrine pathways between the gut and the brain, the gut microbiota have the ...