Multiple manifestations of genetic and non-genetic factors in Multiple Sclerosis disentangled with a multi-omics approach to accelerate personalised medicine KU Leuven
The complex interactions between genetic and non-genetic factors produce heterogeneities in patients as reflected in the diversity of pathophysiology, clinical manifestations, response to therapies, disease development and progression. Yet, the full potential of personalized medicine entails biomarker-guided delivery of efficient therapies in stratified patient populations.
MultipleMS will therefore develop, validate, and exploit ...
Background: Multiple sclerosis is an autoimmune disease in which disease heterogeneity is poorly understood. Improving our understanding of pathways that determine inter-patient variation generates new insights that can advance the therapeutic landscape with tailored treatment options.
Objective: By focusing on imaging, immunology and genetics, we aim to unravel how patients differ from one another and how mechanistically different ...
Somatic mutations explain missing risk in multiple sclerosis
An Goris, Laboratory for Neuroimmunology, KU Leuven
1. State of the art
Multiple sclerosis (MS) is an autoimmune disease of the central nervous system, affecting 2.5 million
people worldwide and leading to important physical and cognitive disability with typical onset during
young adulthood. A genetic component has long been demonstrated and through ...
Getting a grip on slippery protein modifications in the immunopathology of multiple sclerosis Hasselt University
Multiple Sclerosis, a multidisciplinary approach. University of Antwerp
Study of the role of NF-kB regulatory signalling molecules involved in multiple sclerosis through gene targeting in the mouse Ghent University
In this project we investigate the role of NF-kB in multiple sclerosis. Therefore we make use of knockout mice that are deficient in specific NF-kB regulatory genes, and we use these mice in models of multiple sclerose. In this way we hope to better understand the function of specific genes in multiple sclerosis.
Investigating precision in predictive coding during walking to music and metronomes in progressive multiple sclerosis and cerebellar disease. Hasselt University
Multiple sclerosis (MS) is a common neuroinflammatory disorder. MS typically affects young adults and can lead to important physical and cognitive disability at a crucial stage in their life. There are approximately 13,500 individuals suffering from the disease in Belgium, and 2.5 million worldwide. Characteristics of the disease are inflammation, demyelination and axonal loss in brain and spinal cord. In collaboration with colleagues ...