Projects
Automation of a mucin mRNA isoform-based biomarker platform to monitor patients with inflammatory bowel diseases. University of Antwerp
The transmembrane mucin isoform landscape: a new paradigm in gastrointestinal barrier dysfunction (MORSE). University of Antwerp
Mucin isoform-microbiome crosstalk shaping the course of COVID-19: a help in patient stratification? University of Antwerp
A mucin isoform-based biomarker assay to improve follow-up and treatment of inflammatory bowel diseases (IBD) and gastrointestinal (GI) cancers. University of Antwerp
161Tb-labeled radiopharmaceuticals targeting mucin receptors for treatment of pancreatic cancer KU Leuven
Pancreatic ductal adenocarcinoma (PDAC) is one of the most deadliest cancers worldwide with a five-year survival rate of less than 10%. To improve patient prognosis, there is an urgent need for the development of more effective therapeutic strategies. Targeted radionuclide therapy (TRNT) is an established, evidence-based treatment modality where a radioactive ligand (i.e. radiopharmaceutical) is injected intravenously allowing targeted ...
Mucin isoform-microbiome crosstalk shaping the course of COVID-19: a help in patient stratification? Institute of Tropical Medicine
Using mucins as friends in colorectal cancer diagnostics and treatment KU Leuven
We showed that half of the colorectal polyps and tumors, termed iCMS3, develop through differentiation of mature colonocytes into gastric-type, metabolically-skewed neoplastic cells. These cells and tumors show overexpression, production and presentation of gastric and colonic type mucins. In these iCMS3 tumors, we observe high T cell infiltration, but these are incompletely reactive and hence incompetent at clearing the tumor.
Moreover, ...
Using mucins as friends in colorectal cancer diagnostics and treatment KU Leuven
Education 2019.09-2022.07 The Sixth Affiliated Hospital, Sun Yat-sen University Major: General Surgery Mentor: Prof. Xianrui Wu (Professor, Colorectal Surgery) 2014.08-2019.07 Zhongshan School of Medicine, Sun Yat-sen University Major: Clinical Medicine Researches: 2019.09-2022.09 Direction 1: The immune microenvironment and methylation level of colorectal cancer (CRC) for its development and metastasis Abstract: Focusing on the ...