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Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics KU Leuven
Mitochondria-associated membranes (MAMs) are central microdomains that fine-tune bioenergetics by the local transfer of calcium from the endoplasmic reticulum to the mitochondrial matrix. Here, we report an unexpected function of the endoplasmic reticulum stress transducer IRE1α as a structural determinant of MAMs that controls mitochondrial calcium uptake. IRE1α deficiency resulted in marked alterations in mitochondrial physiology and energy ...
Loss of function of XBP1 splicing activity of IRE1α favors B cell tolerance breakdown Ghent University Flanders Institute for Biotechnology
Anti-nuclear antibodies are the hallmark of autoimmune diseases such as systemic lupus erythematosus (SLE) and scleroderma. However, the molecular mechanisms of B cell tolerance breakdown in these pathological contexts are poorly known. The study of rare familial forms of autoimmune diseases could therefore help to better describe common biological mechanisms leading to B cell tolerance breakdown. By Whole-Exome Sequencing, we identified a new ...
The ETHYLENE RESPONSE FACTORs ERF6 and ERF11 antagonistically regulate mannitol-induced growth inhibition in Arabidopsis Ghent University
Leaf growth is a tightly regulated and complex process, which responds in a dynamic manner to changing environmental conditions, but the mechanisms that reduce growth under adverse conditions are rather poorly understood. We previously identified a growth inhibitory pathway regulating leaf growth upon exposure to a low concentration of mannitol and characterized the ETHYLENE RESPONSE FACTOR (ERF)/APETALA2 transcription factor ERF6 as a central ...
A combined ″omics″ approach identifies NMI as a novel cytokine-induced regulator of IRE1α and JNK in pancreatic beta cells KU Leuven Ghent University
Type 1 diabetes (T1D) is an autoimmune disease with a strong inflammatory component. The cytokines interleukin-1β and interferon-γ contribute to beta cell apoptosis in T1D. These cytokines induce endoplasmic reticulum stress and the unfolded protein response (UPR), contributing to loss of beta cells. IRE1α, one of the UPR mediators, triggers insulin degradation and inflammation in beta cells and is critical for the transition from ...
Role of AMACR (alpha-methylacyl-CoA racemase) and MFE-1 (peroxisomal multifunctional enzyme-1) in bile acid synthesis in mice KU Leuven
Cholesterol is catabolized to bile acids by peroxisomal β-oxidation in which the side chain of C27-bile acid intermediates is shortened by three carbon atoms to form mature C24-bile acids. Knockout mouse models deficient in AMACR (α-methylacyl-CoA racemase) or MFE-2 (peroxisomal multifunctional enzyme type 2), in which this β-oxidation pathway is prevented, display a residual C24-bile acid pool which, although greatly reduced, implies the ...
Towards a better understanding of ERG11 biology in the model organism Saccharomyces cerevisiae and in the opportunistic human pathogen Candida albicans KU Leuven
Fungal infections pose an ever increasing threat, due to the growing number of immunocompromised patients and the establishment of resistance to all known antifungal agents. Patients suffering from invasive fungal infections have around 50% chances of survival, stressing the need for new or more efficient antifungal therapies. In my thesis, I have focused on Candida albicans, the most frequently isolated fungal pathogen, and how it can tolerate ...
Manitoba-oculo-tricho-anal (MOTA) syndrome is caused by mutations in FREM1 KU Leuven
Background Manitoba-oculo-tricho-anal (MOTA) syndrome is a rare condition defined by eyelid colobomas, cryptophthalmos and anophthalmia/microphthalmia, an aberrant hairline, a bifid or broad nasal tip, and gastrointestinal anomalies such as omphalocele and anal stenosis. Autosomal recessive inheritance had been assumed because of consanguinity in the Oji-Cre population of Manitoba and reports of affected siblings, but no locus or cytogenetic ...
Mike11 model Leie, Bovenschelde en Gentse Kanalen: beschrijving versie 2015 Flanders Hydraulics
Het WL beschikt over een aantal 1D hydrodynamische modellen van de bevaarbare waterlopen in Vlaanderen. Deze modellen werden opgemaakt met het softwarepakket Mike11 (DHI). Dit rapport beschrijft de opbouw van het 1D-model van de Leie, de Bovenschelde en de Gentse Kanalen (LBSGK).
Mike11 model Demer: beschrijving versie 2015 Flanders Hydraulics
Het WL beschikt over een aantal 1D hydrodynamische modellen van de bevaarbare waterlopen in Vlaanderen. Deze modellen werden opgemaakt met het softwarepakket Mike11 (DHI). Dit rapport beschrijft de opbouw en de validatie van het 1D-model van de Demer.