Publications
Generalizing Demonstrated Motions and Adaptive Motion Generation using an Invariant Rigid Body Trajectory Representation KU Leuven
Skipped fluorination motifs : synthesis of building blocks and comparison of lipophilicity trends with vicinal and isolated fluorination motifs Ghent University
Interactions via intrinsically disordered regions: what kind of motifs? Vrije Universiteit Brussel
SLIDER: Mining correlated motifs in protein-protein interaction networks Hasselt University
Leucine Motifs Stabilize Residual Helical Structure in Disordered Proteins Vrije Universiteit Brussel
Many examples are known of regions of intrinsically disordered proteins that fold into α-helices upon binding to their targets. These helical binding motifs (HBMs) can be partially helical also in the unbound state, and this so-called residual structure can affect binding affinity and kinetics. To investigate the underlying mechanisms governing the formation of residual helical structure, we assembled a dataset of experimental helix contents ...
Unique structural features and sequence motifs of proline utilization A (PutA) Vrije Universiteit Brussel
Proline utilization A proteins (PutAs) are bifunctional enzymes that catalyze the oxidation of proline to glutamate using spatially separated proline dehydrogenase and pyrroline-5-carboxylate dehydrogenase active sites. Here we use the crystal structure of the minimalist PutA from Bradyrhizobium japonicum (BjPutA) along with sequence analysis to identify unique structural features of PutAs. This analysis shows that PutAs have secondary ...