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Minimum end-tidal sevoflurane concentration necessary to prevent movement during a constant rate infusion of morphine, or morphine plus dexmedetomidine in ponies Ghent University

Miguel Gozalo Marcilla, Klaus Hopster, Frank Gasthuys, Anna Elisabeth Krajewski, Andrea Schwarz, Stijn Schauvliege
Objective : To compare the effects of a constant rate infusion (CRI) of dexmedetomidine and morphine to those of morphine alone on the minimum end-tidal sevoflurane concentration necessary to prevent movement (MAC(NM)) in ponies. Study design : Prospective, randomized, crossover, 'blinded', experimental study. Animals : Five healthy adult gelding ponies were anaesthetized twice with a 3-week washout period. Methods : After induction of ...

Direct quantification of morphine glucuronides and free morphine in urine by liquid chromatography-tandem mass spectrometry Ghent University

Koen Deventer, OJ Pozo, Frans Delbeke, Peter Van Eenoo
A simple and robust liquid chromatographic-tandem mass spectrometric method was developed and validated for the direct quantification of the structural isomers morphine-3-glucuronide (M3G), morphine-6-glucuronide (M6G), and morphine in urine. Method development showed that dilution of the urine samples was mandatory to obtain reproducible chromatography and that the use of deuterated internal standards was needed to compensate for ion ...

The influence of morphine on cerebral 5-HT2A availability in dogs Vrije Universiteit Brussel Ghent University

Antita M Adriaens, Ingeborgh E Polis, Simon T Vermeire, Tim Waelbers, Stanislas Sys, Sylvia Van Dorpe, Jos Leon Eersels, Bart De Spiegeleer, Kathelijne Peremans

UNLABELLED: The opioid and serotonergic systems are closely involved in pain processing and mood disorders. The aim of this study was to assess the influence of systemic morphine on cerebral serotonin 2A receptor (5-HT(2A)) binding in dogs using SPECT with the 5-HT(2A) radioligand (123)I-5I-R91150.

METHODS: 5-HT(2A) binding was estimated with and without morphine pretreatment in 8 dogs. The 5-HT(2A) binding indices in the frontal, ...

Antinociceptive and Adverse Effects of μ- and κ-Opioid Receptor Agonists: A Comparison of Morphine and U50488-H KU Leuven

Theo Meert
Although mu-opioids such as morphine are undoubtedly effective in the treatment of acute and postoperative pain, kappa-opioids are of interest for the modulation of visceral pain. In the present study, we compared a kappa-opioid agonist (U50488-H; 0.63-40 mg/kg) with a mu-opioid agonist (morphine; 0.63-40 mg/kg) in different pain models (tail withdrawal, writhing, formalin and plantar test) to represent acute, peritoneovisceral and inflammatory ...

The balance of MU-opioid, dopamine D2 and adenosine A2A heteroreceptor complexes in the ventral striatal-pallidal GABA antireward neurons may have a significant role in morphine and cocaine use disorders Ghent University

Dasiel O. Borroto-Escuela, Karolina Wydra, Ramon Fores-Pons, Lakshmi Vasudevan, Wilber Romero-Fernandez, Malgorzata Frankowska, Luca Ferraro, Sarah Beggiato, Minerva Crespo-Ramirez, Alicia Rivera, et al.
The widespread distribution of heteroreceptor complexes with allosteric receptor-receptor interactions in the CNS represents a novel integrative molecular mechanism in the plasma membrane of neurons and glial cells. It was proposed that they form the molecular basis for learning and short-and long-term memories. This is also true for drug memories formed during the development of substance use disorders like morphine and cocaine use disorders. ...

The effect of morphine on regional cerebral blood flow measured by 99mTc-ECD SPECT in dogs Vrije Universiteit Brussel Ghent University

Antita Adriaens, Kathelijne Peremans, Tim Waelbers, Eva Vandermeulen, Siska Croubels, André Dobbeleir, Kurt Audenaert, Jos Leon Eersels, Simon Vermeire

To gain insights into the working mechanism of morphine, regional cerebral blood flow (rCBF) patterns after morphine administration were assessed in dogs. In a randomized cross-over experimental study, rCBF was estimated with 99mTc-Ethylcysteinate Dimer single photon emission computed tomography in 8 dogs at baseline, at 30 minutes and at 120 minutes after a single bolus of morphine. Perfusion indices (PI) in the frontal, parietal, temporal ...

The effect of prolonged exposure to morphine on canine cerebral 5-HT2A receptors measured with (123)I-R91150 SPECT Vrije Universiteit Brussel Ghent University

Antita Adriaens, Ingeborgh Polis, Simon Vermeire, Tim Waelbers, Siska Croubels, Sylvia Van Dorpe, Jos Leon Eersels, Bart De Spiegeleer, Kathelijne Peremans

Down-stream neuronal alterations, including changes in the 5-HT-2A receptor system, play an important role in the etiology and treatment of depression. The present study examined the effect of prolonged opioid treatment on cerebral 5-HT2A receptors. Cerebral 5-HT2A receptor availability was estimated in seven healthy five-year-old female neutered Beagle dogs pre and post 10-day morphine treatment (oral sustained release morphine 20mg twice ...

Determining the Minimal Clinical Important Difference for Medication Quantification Scale III and Morphine Milligram Equivalents in Patients with Failed Back Surgery Syndrome Vrije Universiteit Brussel

Lisa Goudman, Ann De Smedt, Patrice Forget, Maarten Moens

The Medication Quantification Scale III (MQS) is a tool to represent the negative impact of medication. A reduction in medication can serve as an indicator to evaluate treatment success. However, no cut-off value has yet been determined to evaluate whether a decrease in medication is clinically relevant. Therefore, the objective is to estimate the thresholds for the MQS and morphine milligram equivalents (MMEs) that best identify a clinically ...