Publications
Efficacy of miltefosine in the treatment of visceral leishmaniasis after a decade of use in India Institute of Tropical Medicine
Relapse after treatment with miltefosine for visceral leishmaniasis is associated with increased infectivity of the infecting Leishmania donovani strain Institute of Tropical Medicine
Validation of a simple resazurin-based promastigote assay for the routine monitoring of miltefosine susceptibility in clinical isolates of Leishmania donovani Institute of Tropical Medicine
Increasing failure of miltefosine in the treatment of kala-azar in Nepal and the potential role of parasite drug resistance, re-infection or non-compliance Institute of Tropical Medicine
Drug susceptibility in Leishmania isolates following miltefosine treatment in cases of visceral leishmaniasis and post Kala azar dermal leishmaniasis Institute of Tropical Medicine
The sensitivity of clinical isolates of Leishmania from Peru and Nepal to miltefosine Institute of Tropical Medicine
Failure of miltefosine treatment for visceral leishmaniasis in children and men in South-East Asia Institute of Tropical Medicine
BACKGROUND: High frequency of relapse in miltefosine-treated visceral leishmaniasis (VL) patients in India and Nepal followed up for twelve months.
OBJECTIVE: To identify epidemiological and clinical risk factors for relapse of VL in patients recently treated with standard dosing of miltefosine in India and Nepal.
DESIGN: Prospective observational study in three Primary Health Centers and one reference center in Muzaffarpur ...
Miltefosine enhances the fitness of a non-virulent drug-resistant Leishmania infantum strain University of Antwerp
Failure of miltefosine in visceral leishmaniasis is associated with low drug exposure Institute of Tropical Medicine University of Antwerp
Background. Recent reports indicated high miltefosine treatment failure rates for visceral leishmaniasis (VL) on the Indian subcontinent. To further explore the pharmacological factors associated with these treatment failures, a population pharmacokinetic-pharmacodynamic study was performed to examine the relationship between miltefosine drug exposure and treatment failure in a cohort of Nepalese patients with VL.Methods. Miltefosine ...