CHARACTERIZATION OF α-SYNUCLEIN AGGREGATION, NEURODEGENERATION AND NEUROINFLAMMATION IN MODELS OF PARKINSON’S DISEASE KU Leuven
Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by bradykinesia, resting tremor and muscle rigidity. The pathological hallmarks of PD are the loss of the dopaminergic (DA) neurons in the substantia nigra (SN) and the presence of intracellular protein inclusions called Lewy bodies (LBs).
Alpha-synuclein (α-SYN) is a small protein of 140 amino acids, which is ubiquitously expressed in the brain. α-SYN is ...