BETA-LACTAMASE INHIBITORS Flanders Institute for Biotechnology
The present invention relates to the field of microbiology, in particular to the field of bacterial antibiotic resistance, more particularly to the field of resistance to beta-lactam inhibitors. The invention provides non-natural compounds which induce the aggregation of beta-lactamases, particularly beta-lactamases of class A. In addition, the invention provides combination therapies and pharmaceutical compositions between the non-natural molecules and beta-lactam antibiotics.