Publications
Time to detection of the growth of **Mycobacterium tuberculosis** in MGIT 960 for determining the early bactericidal activity of antituberculosis agents University of Antwerp
Re-evaluation of critical concentrations of antituberculosis fluoroquinolones in the mycobacteria growth indicator tube 960 System Institute of Tropical Medicine
Fluoroquinolones (FQs) have substantial activity against the Mycobacterium tuberculosis complex (MTBc) by preventing bacterial DNA synthesis through DNA gyrase inhibition. The reference standard for FQ-resistance testing is phenotypic drug-susceptibility testing (pDST) based on growth inhibition of MTBc in drug-containing Mycobacteria Growth Indicator Tube system (MGIT) media at a critical concentration (CC) that ...
Re-evaluation of critical concentrations of antituberculosis fluoroquinolones in the Mycobacteria Growth Indicator Tube 960 system University of Antwerp
Evaluation of the BD MGIT TBc Identification Test (TBc ID), a rapid chromatographic immunoassay for the detection of Mycobacterium tuberculosis complex from liquid culture Institute of Tropical Medicine
Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system University of Antwerp
Bedaquiline susceptibility testing of Mycobacterium tuberculosis in an automated liquid culture system Institute of Tropical Medicine
OBJECTIVES: The objective of this study was to evaluate the performance of the BACTEC MGIT960 system to test the susceptibility to bedaquiline for Mycobacterium tuberculosis complex.
METHODS: We determined the quality control (QC) range of bedaquiline using the M. tuberculosis H37Rv reference strain and the epidemiological cut-off (ECOFF) in MGIT960 and on Middlebrook 7H11 agar (M7H11) using 47 strains from bedaquiline treatment-naive ...
Rifampin resistance missed in automated liquid culture system for mycobacterium tuberculosis isolates with specific rpoB mutations University of Antwerp
Rifampicin resistance missed in automated liquid culture system for Mycobacterium tuberculosis with specific rpoB-mutations Institute of Tropical Medicine
Evaluation of a novel line probe assay to detect resistance to pyrazinamide, a key drug used for tuberculosis treatment Institute of Tropical Medicine University of Antwerp
Objectives: The development of rapid molecular diagnostic assays for pyrazinamide (PZA) resistance is considered technically challenging as mutations are highly diverse, scattered along the full length of the pncA gene and not all are associated with PZA resistance. We evaluated the performance of the novel Genoscholar PZA-TB II line probe assay (PZA-LPA2; NIPRO Corporation, Japan).
Methods: To evaluate the applicability of the ...