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Pharmacokinetics of co-formulated mefloquine and artesunate in pregnant and non-pregnant women with uncomplicated Plasmodium falciparum infection in Burkina Faso Institute of Tropical Medicine University of Antwerp

I. Valea, H. Tinto, M Coulibaly, L.C. Toe, N. Lindegardh, J. Tarning, J.P. Van geertruyden, D'Alessandro, G.R. Davies, S.A. Ward, et al.
OBJECTIVES: Mefloquine/artesunate has recently been developed as a fixed-dose combination, providing a promising rescue/alternative treatment for malaria during pregnancy. However, limited data are available on the effect of pregnancy on its pharmacokinetic properties. This study was conducted to assess the pharmacokinetic properties of mefloquine/carboxymefloquine and artesunate/dihydroartemisinin in pregnant and non-pregnant women with ...

Absolute configuration of the antimalarial erythro-mefloquine : vibrational circular dichroism and X-ray diffraction studies of mefloquine and its thiourea derivative Ghent University University of Antwerp

M Kohout, Jelle Vandenbussche, A Roller, J Tuma, J Bogaerts, Patrick Bultinck, W Herrebout, W Lindner
The long-standing discussion of the absolute configuration of erythro-mefloquine is resolved using a combination of experimental and calculated Vibrational Circular Dichroism spectroscopy. This assignment of one of the most important antimalarials is further confirmed by x-ray diffraction-based structure elucidation of thiourea derivates.

Schistosomicidal activity of the antimalarial drug, mefloquine, in **Schistosoma mansoni**-infected mice University of Antwerp

Stephen Toovey, Joeri Van Op den bosch, Jean-Pierre Timmermans, Jozef Vercruysse
Therapeutic effects of racemic mefloquine were assessed in Schistosoma mansoni-infected mice, and evaluated by recording worm burden, the status of egg maturation and viability, and intestinal mast cell recruitment. Age-matched mice were divided into four groups, of which two were infected. At 8 weeks postinfection, one group of infected and one group of uninfected mice were treated with a single dose of mefloquine (150 mg/kg). Ten days after ...

Structure-switching aptamer sensors for the specific detection of piperaquine and mefloquine KU Leuven

Maarten De Vos
Tracking antimalarial drug use and efficacy is essential for monitoring the current spread of antimalarial drug resistance. However, available methods for determining tablet quality and patient drug use are often inaccessible, requiring well-equipped laboratories capable of performing liquid chromatography-mass spectrometry (LC-MS). Here, we report the development of aptamer-based fluorescent sensors for the rapid, specific detection of the ...

Risks of hemolysis in glucose-6-phosphate dehydrogenase deficient infants exposed to chlorproguanil-dapsone, mefloquine and sulfadoxine-pyrimethamine as part of intermittent presumptive treatment of malaria in infants University of Antwerp

Eugenie Poirot, Eric Vittinghoff, Deus Ishengoma, Michael Alifrangis, Ilona Carneiro, Ramadhan Hashim, Vito Baraka, Jacklin Mosha, Samwel Gesase, Daniel Chandramohan, et al.
Background Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children. Few studies have explored the effects of G6PD status on hemolysis in children treated with Intermittent Preventive Treatment in infants (IPTi) antimalarial regimens. We sought to examine the joint effects of G6PD status and IPTi antimalarial treatment on incidence of hemolysis in asymptomatic children ...

Evaluation of artesunate-mefloquine as a novel alternative treatment for schistosomiasis in African children (SchistoSAM): protocol of a proof-of-concept, open-label, two-arm, individually-randomised controlled trial Institute of Tropical Medicine

Clémentine Roucher, Isabel Brosius, Moustapha Mbow, Babacar Thiendella Faye, Annelies De Hondt, Bart Smekens, Diana Arango, Christophe Burm, Achilleas Tsoumanis, Linda Paredis, et al.

INTRODUCTION: Alternative drugs and diagnostics are needed for the treatment and control of schistosomiasis. The exclusive use of praziquantel (PZQ) in mass drug administration programmes may result in the emergence of drug resistance. PZQ has little activity against Schistosoma larvae, thus reinfection remains a problem in high-risk communities. Furthermore, the insufficient sensitivity of conventional microscopy hinders therapeutic response ...

Molecular surveillance of Plasmodium falciparum drug-resistance markers in Vietnam using multiplex amplicon sequencing (2000-2016) Institute of Tropical Medicine

Eduard Rovira-Vallbona, Eline Kattenberg, Nguyen Van Hong, Pieter Guetens, Hideo Imamura, Pieter Monsieurs, Driss Chiheb, Annette Erhart, Bui Quang Phuc, Nguyen Xuan Xa, et al.

Emergence and spread of Plasmodium falciparum resistance to artemisinin-based combination therapies (ACT) is a major challenge for Greater Mekong Subregion countries in their goal to eliminate malaria by 2030. Tools to efficiently monitor drug resistance beyond resource-demanding therapeutic efficacy studies are necessary. A custom multiplex amplicon sequencing assay based on Illumina technology was designed to target the marker of partial ...

The influence of pregnancy on the pharmacokinetic properties of artemisinin combination therapy (ACT) Institute of Tropical Medicine

Benjamin Jelle Visser, Martin P. Grobusch, Michele van Vugt

Background: Pregnancy has been reported to alter the pharmacokinetic properties of anti-malarial drugs, including the different components of artemisinin-based combination therapy (ACT). However, small sample sizes make it difficult to draw strong conclusions based on individual pharmacokinetic studies. The aim of this review is to summarize the evidence of the influence of pregnancy on the pharmacokinetic properties of different ...