Study on the mechanisms underlying mast cell activation in postinfectious visceral hypersensitivity KU Leuven
Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder characterized by chronic discomfort and abdominal pain associated with altered defecation in the absence of an organic cause. It is becoming increasingly clear that mast cell activation, leading to activation and sensitization of afferent nerves, plays a crucial role in abnormal visceral pain sensation (visceral hypersensitivity), one of the hallmarks of IBS. However, the ...