Projects
Scrutinizing the role of mast cells during human and murine Leishmania infections KU Leuven
Despite a global distribution of Leishmaniasis and 1.5 to 2 million new cases annually, no effective human vaccines are available and treatment failure with current drugs is on the rise. Mast cells (MCs) are immune sentinels in the skin that are amongst the first to contact the Leishmania parasite following a sand fly bite. These cells play major roles in orchestrating early inflammatory responses, regulating vascular permeability and ...
Scrutinizing the role of mast cells during human and murine Leishmania infections. University of Antwerp
The role of the GATA transcription factors in the development and function of mast cells in asthma. Ghent University
A conditional GATA knock-out will be induced in mastcells by using Cre/loxP technology. In vitro experiments will define the expression pattern of Gata-genes en their regulators during development of mast cells and the effect og gata-deficiency on the development and funtion of mastcells. In vivoo experiments will define the effects of GATA-deficiency in a mousemodel of asthma.
The role of mast cells in the restriction of CNS inflammation after brain trauma and spinal cord injury Hasselt University
The role of mast cells in the restriction of CNS inflammation after spinal cord injury Hasselt University
Peroxisomes in mast cells – their functions and link to airway inflammation Ghent University
This project will focus on peroxisomal functions and their involvement in inflammatory processes in the
context of chronic rhinosinusitis. The emphasis on the investigations will be put on the peroxisomes of mast
cells. The experiments will be done on human ex vivo nasal tissue and murine models.