Projects
Zebrafish as a novel model host for morphological and undiscovered immunl characteristics of in vivo Candida albicans biofilms KU Leuven
In nature, most microorganisms exist predominantly as a community of cells, called a
biofilm, where they adhere to and live on various surfaces. Cells present in such a
biofilm acquire different characteristics compared to planktonic cells, such as altered
survival, growth and virulence. The human fungal pathogen Candida albicans is also
well-known for its ability to form biofilms, both on mucosal surfaces as ...
Exploring the neuro-immune mechanisms underlying nasal hyperreactivity in rhinitis and rhinosinusitis KU Leuven
Rhinitis can present with nasal obstruction, nasal discharge, itch, or sneezing. In case of involvement of the paranasal sinuses (i.e. rhinosinusitis), facial pain or loss of smell is possible as well. Several endotypes of rhinitis and rhinosinusitis are known, such as type 1 or type 2 inflammation.
Allergic rhinitis (AR) and chronic rhinosinusitis with nasal polyps (CRSwNP) are both characterized by a mainly type 2 inflammation in the ...
Triple punch against melanoma: photodynamic therapy, immunogenic cell death and photothermal ablation Ghent University
The rapid growth of cancer immunotherapy offers a new perspective for designing effective treatments. However, often responses are low since tumours exhibit different resistance mechanisms. This proposal will combine photodynamic therapy with photothermal ablation based on nanocapsules and nanothermometers, aiming to trigger immunogenic cell death and induce efficient anti-tumour immunity. It will improve the efficacy of cancer ...
The role of mucosal mediators and their effect on neuronal afferent signalling and intestinal permeability during postinflammatory visceral hypersensitivity: a translational study. University of Antwerp
Neuro-immune mechanisms of visceral and respiratory hypersensitivity KU Leuven
Neuro-immune mechanisms of visceral hypersensitivity KU Leuven
Infla-Med: Fundamental and translational research into targets for the treatment of inflammatory diseases. University of Antwerp
SRP-Groeifinanciering: Physical exercise to counteract inflammation in ageing Vrije Universiteit Brussel
The role of pili on Lactobacillus rhamnosus GG in the interaction with macrophages and other immune cells KU Leuven
The human gastrointestinal tract is colonized by large numbers of microbes, referred to as the gut microbiota. This microbiota establishes a complex and bilateral interplay with local host cells such as epithelial and immune cells. Functions including contribution to digestion, pathogen exclusion, enhancement of the epithelial barrier functioning and immune system modulation have been attributed to these gut microorganisms. Their described ...