Projects
Induction of IgA2 class switching in human Ige+B cells as theraphy for allergic disease Ghent University
Abstract (max. 60 woorden): IgE plays a central role in allergy by activating mast cells and facilitating allergen presentation to Th2 lympghocytes. Accumulating evidence suggests that IgA plays a protective role in allergy by antagonizing the effects of IgE. Therefore using three proven IgA promoting regimens: IL-21+TGFB1, cholera toxin B (CTB) and Lactococci engineerd to express allergen and CTB
Bidirectional communication between the enteric nervous system and elements of the immune system in inflammatory gastrointestinal disorders. University of Antwerp
Drug-induced anaphylaxis via MRGPRX2 occupation: introduction of a new human model. University of Antwerp
Are mas-related gene receptors involved in irritable bowel syndrome? University of Antwerp
Anaesthesia-related allergy: from new insights in pathomechanisms to reliable diagnostic instruments. University of Antwerp
Mechanobiology control of immunogenic cell death by bio-polymers for cancer therapy Ghent University
Immunogene celdood (ICD) combineert het vermogen om zowel kankercellen te doden als tegelijkertijd anti-tumorimmuniteit te activeren, en impliceert ferroptose, wat een efficiënte antikankerstrategie representeert. Eén van de belangrijkste knelpunten voor ferroptose en andere ICD-modaliteiten is de effectieve inductie van opname van stervende kankercellen die ICD ondergaan door fagocyten. In ongepubliceerd onderzoek waarbij een nieuw en ...
Controlled delivery of connexin43 mimetic peptide by nanocontainers for therapy of systemic inflammation Ghent University
Acute systemic inflammation is often associated with many severe life- threatening diseases. We found that connexin43 mimetic peptides are effective when applied prophylactically, while they lose their effectiveness when injected after the onset of systemic inflammation. We aim to develop nanocontainers capable of high loading of connexin43 peptides and their sustained release to ameliorate the signs of systemic inflammation.