Projects
Functional characterisation of gut mast cells in irritable bowel syndrome. University of Antwerp
Peroxisomes in mast cells – their functions and link to airway inflammation Ghent University
This project will focus on peroxisomal functions and their involvement in inflammatory processes in the
context of chronic rhinosinusitis. The emphasis on the investigations will be put on the peroxisomes of mast
cells. The experiments will be done on human ex vivo nasal tissue and murine models.
Mast cell activation tests (MAT): from an innovative diagnostic to the expansion of a service facility. University of Antwerp
Exploring the role of a novel mast cell activation pathway in IBD and IBS models. University of Antwerp
Mechanisms and Diagnosis of Mast Cell and Basophil Activation in Rare Hypersensitivity Disorders KU Leuven
Hypersensitivity is an exaggerated response of the immune system to harmless triggers. In Type I hypersensitivity or allergy, effector cells (mast cells and basophils) are activated through allergen-induced cross-linking of surface-bound allergen-specific IgE antibodies, leading to degranulation and systemic release of inflammatory mediators. This can result in a potentially life-threatening rapid-onset clinical syndrome affecting the ...
Scrutinizing the role of mast cell during human and murine Trypanosoma infections. University of Antwerp
Mast cell driven immediate drug hypersensitivity: resolving the specific IgE versus MRGPRX2 conundrum University of Antwerp
Using molecular signaling profile in white blood cells measured by highly-sensitive mass spectrometry (MS)-based proteomics in the differential diagnosis between major depressive disorder and bipolar disorder. University of Antwerp
Multi-omics approach to identify pancreatic cancer biomarkers in liquid biopsies of advanced stage patients by pioneering single cell mass spectrometry of CTCs and (epi)genetics characterization of cfDNA Ghent University
Pancreatic cancer is a deadly disease with surgery the only chance for cure. Surgeons have to evaluate whether patients with advanced pancreatic cancer will benefit from surgery. Current diagnostic tools (imaging and CA19-9), are inadequate, with early recurrence and metastases seen in up to 40% of patients. To address this, a multi-omics approach is proposed to identify PDAC biomarkers in liquid biopsies with higher accuracy, sensitivity, ...