Projects
Investigation of the structural and functional role of the Plasmodium falciparum circumsporozoite protein in the development of liver stage malaria. University of Antwerp
Hemozoin vaccination as a new concept for the prevention of malaria pathology. KU Leuven
New Concepts for the Prevention and Treatment of Malaria Pathology. KU Leuven
Malaria is a major global disease causing >200 million clinical cases and >600 000 deaths each year. Upon transmission by Anopheles mosquitoes and after a clinically silent liver stage, the parasite infects red blood cell and can cause life-threatening complications. These complications arise from immune evasion by the parasite, and inappropriate immune reactions may also contribute.
Our research focuses on the pathogenesis of ...
Intermittent preventive treatment of malaria in school children: from research into policy. University of Antwerp
Investigation of the structure-function relationship of sporozoite 6Cys proteins from the malaria parasite Plasmodium vivax. University of Antwerp
A geostatistical framework to forecast malaria incidence in the context of climatic events KU Leuven
Malaria is a life-threatening disease that causes a significant public health burden worldwide. Malaria incidences show considerable temporal and geographical variation, which can be linked at least partly to climatic conditions. Over the last twenty years, multiple Malaria Early Warning Systems (MEWS) have been developed. These systems primarily focus on short-term incidence predictions, but there is a growing demand to implement long-term ...
Macrocyclic lactones as an additional measure for malaria parasite and vector control in Ethiopia Ghent University
Current malaria control measures have led to a change in vector comportment which brings a new challenge to target outdoor malaria transmission. Comparative efficacy and pharmacokinetic studies of different macrocyclic lactones (MLs) will be done in local cattle breeds targeting the vector
mosquitoes. Next, the MLs will be evaluated and compared regarding their sporontocidal and gametocytocidal effect on the malaria parasite.
The role of the mosquito vector in arbovirus drug resistance: how to avoid a 'malaria scenario'? KU Leuven
Arboviruses can cause severe diseases such as hemorrhagic fever, encephalitis and arthritis. Some of these viruses including Dengue virus and chikungunya virus are significant global health threats because of their high disease burden, their widespread (re-)emergence and the lack of vaccines or therapeutics. Furthermore, there is a lack of knowledge on the potential emergence of drug-resistant arboviruses. The worldwide spread of ...