Projects
The impact of artesunateamodiaquine retreatment and specific malaria humoral immunity on recrudescent malaria infections. University of Antwerp
Eco epidemiology of asymptomatic malaria hotspots, a prerequisite for malaria elimination? Institute of Tropical Medicine
Investment in malaria elimination is believed to provide one of the highest returns in global health. Elimination however requires a different approach as compared to what is done in present control programs. New insights in the eco-epidemiology of the malaria parasites will be essential in defining this approach, especially for Plasmodium vivax of which current knowledge is relatively poor. In the proposed research program we seek to ...
Reducing severe malaria related child mortality in the Democratic Republic of Congo (DRC) by improving the management and control of malaria associated kidney injury (MAKI) KU Leuven
Malaria and its complications, including kidney injury, remain a leading cause of child mortality in the DRC.Acute kidney injury (AKI) is emerging as a complication of increasing clinical importance associated withsubstantial morbidity and mortality in children with severe malaria. AKI was identified as the strongest predictorof mortality alongside coma in African children with severe malaria. Data from our previous VLIR-UOS projectsnoted a ...
Statistical methods for the estimation of age- and time-dependent epidemiological malaria parameters and the analysis of social network data as a novel approach to design malaria elimination strategies. University of Antwerp
The impact of artesunateamodiaquine retreatment and specific malaria humoral immunity on recrudescent malaria infections. Institute of Tropical Medicine
In ...
Investigation of the structural and functional role of the Plasmodium falciparum circumsporozoite protein in the development of liver stage malaria. University of Antwerp
Glucocorticoid regulation of systemic immunometabolism in malaria KU Leuven
Malaria is a parasitic disease that poses a major health threat to the world with an estimated 219 million cases and 435000 deaths in 2017. Especially the complications of malaria are life-threatening and have ~15% fatality rates despite antimalarial treatment. These complications include amongst others cerebral malaria, severe anemia and respiratory problems and are further worsened by metabolic disturbances, such as hypoglycemia and ...
Hemozoin vaccination as a new concept for the prevention of malaria pathology. KU Leuven
Safe and efficacious artemisinin-based combination treatments for African pregnant women with malaria. Institute of Tropical Medicine
Overall Goal: To identify artemisinin-based combination treatments (ACT) that can be safely and efficaciously used to treat women with malaria in their second and third trimester of pregnancy. This will be attained through the following strategies: 1. Research: To determine the safety and efficacy of 4 ACTs when administered to pregnant women during the second and the third trimester with P. falciparum infection and collect explanatory ...