Projects
Detection, isolation and culture of liver progenitor cells after liver resection in a model of chronic liver damage in the rat University of Antwerp
Alterations in hepatic drug metabolism in children with severe chronic liver disease and in pediatric liver transplant recipients Ghent University
This project aims to evaluate the differential alterations in hepatic drug metabolism in children with severe chronic liver disease and in pediatric liver transplant recipients, using both in vitro (liver microsomes from surgical waste) and in vivo (probe-cocktail) approaches.
Novel strategies to increase the number and quality of donor lungs for transplantation KU Leuven
Lung transplantation is a lifesaving treatment option in well-selected patient with end-stage lung disease. Due to the successes of lung transplantation, transplant programs are expanding rapidly worldwide. However, two major problems impede optimal outcome early after lung transplantation. First, 10 to 30% of all lung recipients develop primary graft dysfunction, which is the leading cause of early morbidity and mortality after lung ...
An ethical analysis of the impact of recent strategies to promote living organ donation on the moral foundations of organ transplantation Ghent University
Since at least 20 years the domain of transplantation is facing a severe shortage of available organs. Many countries are focusing on boosting living donation as the primary means for increasing the number of organs. To a considerable extent, the rise in the volume of living donation can be explained by the implementation of novel strategies. These include: (1) relaxing acceptable donor categories to allow living donation by total strangers ...
Glycomarker in perfusate for the prediction of liver primary non function Ghent University
Primary non-function (PNF) of a liver after liver transplantation is a complete absence of liver function immediately after liver transplantation. It occurs in 3-8% of liver transplants and is a medical urgency that requires an urgent liver transplant within 24-48h. PNF is related to the quality of the donor liver. Unfortunately, there are no good biomarkers to evaluate the quality of the donor liver. We propose an alternative approach to ...
TAMALE: Tracer-bAsed MApping of Liver mEtabolism KU Leuven
The dynamic mapping of the metabolism and nutrition of the healthy and diseased liver will lead to
metabolic mapping of other organs and ultimately entire biological systems. Understanding how
nutrition and hormonal changes affect cell/organ metabolism obviously paves the way to treatment of
metabolic changes or abnormalities via the use of selective nutrition and medication. There are of course
ramifications ...
Unravelling the heterogeneity and functions of hepatic mononuclear phagocytes in Non-Alcoholic Fatty Liver Disease Ghent University
Non-alcoholic fatty liver disease (NAFLD) results from accumulation of excessive fat in the liver. It encompasses simple steatosis (fatty liver) progressing through non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma. It is the most common cause of chronic liver disease in western countries and is predicted to be the main cause of liver transplantation by 2030. As such NAFLD represents a significant clinical burden ...