iPSC-based parenchymal and sinusoidal liver cell mimics for DILI and NAFLD studies (iPSC-LiMic) KU Leuven
iPSC-LiMic will establish a unique platform in Flanders, and one of the few in Europe, wherein iPSC- derived parenchymal hepatocytes as well as sinusoidal cells (hepatic stellate cells, HSCs; liver sinusoidal endothelial cells, LSECs; and Kupffer cells, KCs) are created from human iPSC and assembled in 3D cocultures (termed 3D iPS-liver mimics), which can be maintained for >20 days in culture. Culture of 3D iPS-Liver mimics will be ...