Study of osteoarthritis-associated genes using zebrafish and chick developmental models. KU Leuven
Osteoarthritis (OA) is a disorder of the synovial joints and a leading cause of impaired movement and pain, affecting millions of people worldwide. The disease is characterized by a progressive degradation of the articular cartilage and associated defects of the subchondral bone. Over the past decades, genetic and environmental risk factors that predispose to OA have been intensively investigated. Remarkably, many of the OA-associated genes ...