Evaluation of a novel line probe assay to detect resistance to pyrazinamide, a key drug used for tuberculosis treatment Institute of Tropical Medicine University of Antwerp
Objectives: The development of rapid molecular diagnostic assays for pyrazinamide (PZA) resistance is considered technically challenging as mutations are highly diverse, scattered along the full length of the pncA gene and not all are associated with PZA resistance. We evaluated the performance of the novel Genoscholar PZA-TB II line probe assay (PZA-LPA2; NIPRO Corporation, Japan).
Methods: To evaluate the applicability of the ...