Modulation of cytokine production by cAMP-analogues in human leukocytes Vrije Universiteit Brussel
Cyclic-AMP is a well-known second messenger that operates through different signaling molecules including protein kinase A (PKA) and guanine exchange proteins directly activated by cAMP (EPAC). It has been shown that cell-permeable cAMP analogues such as 8-(4-chloro-phenyl-thio)-cAMP (8-pCPT-cAMP) modulate cytokine secretion by different leukocyte subsets, including T cells and monocytes. Since cAMP-modulating drugs such as phosphodiesterase ...