Projects
Enhancing Generative and Regenerative Implant Treatments KU Leuven
The treatment of bony defects has been challenging clinicians for many years. After tooth extraction, trauma or periodontal disease, it can occur that sites associated with bony defects will not heal completely or properly. In that instance, additional reconstructive surgery is indicated. Different surgical approaches have been proposed for the treatment of such bony defects, such as Guided Bone Regeneration (GBR). GBR is used to induce the ...
Study of the involvement of the choroid plexus during SIRS Ghent University
This thesis explored multiple aspects that are related to systemic inflammatory response syndrome (SIRS), a prevalent disease with a high mortality and a treatment that is mainly supportive. During SIRS, several cytokines, danger associated molecular patterns (DAMPs), matrix metalloproteinases (MMP), and other inflammatory mediators are induced that lead to the breakdown of brain barriers. Interestingly, our group previously showed that mice ...
In vitro and in vivo glyco-engineering of human IgG, and the leukocyte-cell surface with new fucosidasen Ghent University
Glycosylations on proteins are crucial to achieve correct protein folding, and outside the cell glycans perform numerous other functions. A very active area of research currently concerns the analysis of the role of complex sugars in the immune system1 . In particular, we want to explain how these sugars, and specifically fucose, are critical in both the effector function of antibodies and in the migration of leukocytes to specific sites ...
The marginal zone B cel in concordant xenograft rejection: critical help signals in the T cel-independent type II xenoantibody response and possible targets for xeno-immunosuppression. KU Leuven
Allogeneic hematopoietic stem cell transplantation
(HSCT) and posttransplant adoptive cell therapy with donor leukocyte infusions
(DLI) are known to exert potent graft-versus-leukemiaeffects and convincing
evidence is emerging that this approach can also elicit responses against solid
tumors. Graft-versus-leukemia effects specifically after DLI largely rely
on ...
Evaluating the therapeutic potential of anti-CD6 monoclonal antibody therapy in inflammatory barrier diseases. Hasselt University
Genetic and pharmacological studies of two growth factor receptor tyrosine kinase-ligands in cancer: Gas6 and PlGF KU Leuven
Following cardiovascular diseases, cancer
represents the second mostcommon cause of death in the western world. In 2008
the world healthorganization (WHO) estimated 12,7 million new cancer cases, of
thosecases 7.6 million people die of cancer. Cancer is a heterogeneous class
of diseases, which arises from ...
Biological characterisation of new molecular forms of chemotactic cytokines: role in inflammation and cancer. KU Leuven
Biological characterisation of new molecular forms of chemotactic cytokines: role in inflammation and cancer.
The first dimension of chemokine heterogeneity is reflected by their discovery and purification as natural proteins. Each of those chemokines attracted a specific inflammatory leukocyte type. With the introduction of genomic technologies, a second wave of chemokine heterogeneity was established by the discovery of putative ...
Unraveling the effects of maternal metabolic stress on the uterine environment: focusing on the importance of extracellular vesicles for pre-implantation embryo development in a dairy cow model. University of Antwerp
Neutrophil migration and activation in auto-inflammatory diseases: role of the chemokine network and of posttranslational modification of chemokines KU Leuven
Leukocyte migration is crucial during inflammation. It is regulated by a network of molecules including adhesion molecules, leukocyte attractants such as chemokines and their receptors. Although most leukocyte attractants have been identified, posttranslational modifications affecting their activity are still being discovered. These modifications may increase or decrease the activity of attractants and may even result in the generation of ...