Projects
Using evasins as tools to regulate the activation and recruitment of leukocytes to injury sites KU Leuven
Uncontrolled inflammation is a major public health issue. It is difficult to treat clinically and is not restricted to the devastating pneumonia resulting from covid-19 infections. Thus, there is an urgent need for anti-inflammatory therapies that apply to covid-19 but also to the many inflammatory disorders affecting humans. During evolution, ticks had to circumvent an attack by the immune system of their mammalian host. As such, ticks ...
Using evasins as tools to regulate the activation and recruitment of leukocytes to injury sites KU Leuven
Leukocyte- and Platelet-Rich Fibrin in neurosurgery and skull base surgery KU Leuven
Many procedures in cranial surgery involve the intentional opening of the dura. As the cerebrospinal fluid and dura play an important protective role for the brain, it is important to meticulously close the dura after the surgical procedure. Inadequate dural closure might lead to cerebrospinal fluid (CSF) leakage, which is a major complication in neurosurgery. CSF leakage can lead to secondary complications such as surgical site infection, ...
Stored Leukocyte- and Platelet-Rich Fibrin for Regenerative Therapy KU Leuven
Oral health is an essential component of overall health, especially as it facilitates nutrient absorption, emotional expression, and daily socialization. Good oral health plays a crucial role in promoting both physical and mental development. Oral diseases, despite being highly preventable, are typically neglected in health policy and are gradually becoming a public health problem, affecting over 3.5 billion people globally. Priority oral ...
Novel and enhanced approaches of leukocyte- and platelet-rich fibrin in periodontal and implant surgery KU Leuven
Biomaterials have been introduced in oral surgery many years ago. The most accepted definition is from 1982 and is as follows: “any substance (other than a drug) or combination of substances, synthetic or natural in origin, which can be used for any period of time, as a whole or as a part of a system which treats, augments, or replaces any tissue, organ, or function of the body”. As also described in the definition, biomaterials can be of ...
The neuroregenerative effect of human dental pulp stem cells is enhanced by inflammatory preconditioning with soluble factors contained in Leukocyte- and Platelet Rich Fibrin Hasselt University
Dipeptidyl-peptidase 9 in human leucocytes. University of Antwerp
Novel immunotherapy for high-risk neuroblastoma: allogeneic stem cell transplantation and recipient leukocyte infusion. KU Leuven
Neuroblastoma is the most frequent extra-cranial solid tumor in childhood. More than half of patients is diagnosed with high-risk disease (non-resectable and metastasized), and is faced with poor prognosis. To date, an effective and safe treatment for such patients is not available, urgently necessitating research into novel treatment strategies.
Allogeneic hematopoietic stem cell transplantation is a cornerstone in the treatment of ...