The (pre-) leukemic stem cell as cause of therapeutic failure in pediatric acute myeloid leukemia. Ghent University
Acute Myeloid Leukemia (AML) is a hematological malignancy and the most common type of acute leukemia in adults and the second most frequent type in children, with on average 10-15 children diagnosed per year in Belgium. Despite clinical remission rates of approximately 90%, 30-40% of these children relapse within 3-5 year from diagnosis resulting in a 5 year overall survival rate of 65 -70%. Bone marrow transplantation remains the only ...