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Leptospirosis in dogs: a retrospective study of seven clinical cases in Belgium Ghent University

Anita Claus, Isabel Van de Maele, Frank Pasmans, Kris Gommeren, Sylvie Daminet
Recent information regarding clinical leptospirosis in Europe is sparse in comparison with information about this disease in the United States and certain other countries. A retrospective study describing seven clinical cases of dogs diagnosed with leptospirosis on the basis of a MAT (Microscopic Agglutination Test), serology or autopsy at the Department of Medicine and Clinical Biology of Small Animals, Ghent University between Januarv 2003 and ...

Leptospirosis in Sub-Saharan Africa Institute of Tropical Medicine

Sophia G. de Vries, Benjamin Jelle Visser, Martin P. Grobusch

Background: Leptospirosis is an emerging zoonotic infection worldwide, possibly due to climate change and demographic shifts. It is regarded as endemic in Sub-Saharan Africa; however, for most countries scarce epidemiological data, if any, exist. The primary objectives were to describe the prevalence of leptospirosis in countries in Sub-Saharan Africa, and to develop options for prevention and control in the future.

Methods: A ...

Nucleic acid and antigen detection tests for leptospirosis Institute of Tropical Medicine

Sophia G. de Vries, Benjamin Jelle Visser, Martin P. Grobusch, Mariska M G Leeflang

Background

Early diagnosis of leptospirosis may contribute to the effectiveness of antimicrobial therapy and early outbreak recognition. Nucleic acid and antigen detection tests have the potential for early diagnosis of leptospirosis. With this systematic review, we assessed the sensitivity and specificity of nucleic acid and antigen detection tests.

Objectives

To determine the diagnostic test accuracy of nucleic acid ...

Travel-related leptospirosis in the Netherlands 2009-2016: an epidemiological report and case series Institute of Tropical Medicine

Sophia G. de Vries, Benjamin Jelle Visser, Michele van Vugt, Abraham Goorhuis, Jiri F. P. Wagenaar, Martin P. Grobusch

Background: Leptospirosis is a potentially fatal zoonotic disease that is prevalent in travellers. Here, we describe epidemiological and diagnostic characteristics of all returning travellers diagnosed with leptospirosis in the Netherlands between 2009 and 2016. Furthermore, we present a detailed clinical case series of all travellers with leptospirosis who presented at the Academic Medical Center (AMC) in the same period.

Method: We ...

Environmental and Behavioral Risk Factors for Severe Leptospirosis in Thailand Institute of Tropical Medicine

Soawapak Hinjoy, Somkid Kongyu, Pawinee Doung-Ngern, Galayanee Doungchawee, Soledad Colombe, Royce Tsukayama, Duangjai Suwancharoen
A nationwide prevention and control campaign for leptospirosis in Thailand has led to a decreased incidence rate, but the mortality and case fatality rates have remained stable. Regarding the limited knowledge of risk factors, a case-control study of the association between environmental and behavioral exposure with severe leptospirosis was implemented to identify the risk factors among adults in Thailand. The study was conducted in 12 ...

Favorable course of leptospirosis and hantavirus-induced acute tubulointerstitial nephritis under corticosteroid treatment Ghent University

Jo Dehoorne, Amélie Dendooven, Petra Schelstraete, Agnieszka Prytula-Ebels
BackgroundWe present two children with acute tubulointerstitial nephritis (ATIN) caused by leptospirosis in a 12-year-old boy and hantavirus in a 10-year-old girl. The role of glucocorticoids in the management of ATIN triggered by infectious agents is unclear.Case-diagnosis/treatmentBoth children were hospitalized with jaundice, elevated serum creatinine, and thrombocytopenia. There was no oliguria or hypertension. Urine analysis revealed ...

Leptospirosis in dogs: a review with emphasis on clinical aspects Ghent University

Isabel Van de Maele, Anita Claus, Freddy Haesebrouck, Sylvie Daminet
Leptospirosis is a bacterial disease affecting several mammalian species, including human beings. in dogs, it is spread mainly by rodents that act as a maintenance host for several Leptospira serovars. Until recently, the most common signs observed in affected dogs consisted of icterus and haemorrhagic diathesis, but today the most prevalent clinical signs are attributed to acute renal failure. The current literature gives a good review of ...

Leptospirosis Institute of Tropical Medicine

P.G. Janssens, J Van Riel