Clustering of leprosy beyond the household level in a highly endemic setting on the Comoros, an observational study Institute of Tropical Medicine
BackgroundThe island of Anjouan (Comoros) is highly endemic for leprosy with an annual incidence of 5-10/10,000. In May/June, 2015 single-dose Rifampicin post-exposure prophylaxis (SDR-PEP) was administered to 269 close contacts of 70 leprosy-patients in four villages as a pilot programmatic intervention. Two years later we revisited the villages for follow-up investigations. The main aim of our study was to quantify spatial associations ...
Post kala azar dermal leishmaniasis and leprosy prevalence and distribution in the Muzaffarpur health and demographic surveillance site Institute of Tropical Medicine
Post-kala-azar dermal leishmaniasis (PKDL) is a skin manifestation that is a late clinical outcome of visceral leishmaniasis (VL). Its presentation is similar to leprosy, and the differential diagnosis is not always easy. In VL endemic rural areas of Bihar, India, both infectious diseases co-exist. This observational study aimed to determine the prevalence and distribution of both conditions in an area that had until ...
Leprosy on Anjouan (Comoros): persistent hyper-endemicity despite decades of solid control efforts Institute of Tropical Medicine
Introduction: Despite decades of solid leprosy control efforts, the disease remains highly endemic on the island of Anjouan, Comoros. Among a population of less than 400,000 over 300 new leprosy patients are diagnosed on average annually.
Methods: We analysed routine data for the period of 2000-2015 for trends in epidemiological parameters and clustering in time and space.
Results: Leprosy incidence remains high (7.4/10,000 per ...
Spatial heterogeneity in projected leprosy trends in India Ghent University
Are guidelines for field treatment of leprosy reactions evidence-based? A comprehensive literature review Institute of Tropical Medicine
Recent advances in leprosy and Buruli ulcer (Mycobacterium ulcerans infection) Institute of Tropical Medicine
A longitudinal study of the incidence of leprosy in a hyperendemic area in Zaire, with special reference to PGL-antibody results Institute of Tropical Medicine
A study of alleged leprosy bacillus strain HI-75 Institute of Tropical Medicine
qPCR-High resolution melt analysis for drug susceptibility testing of Mycobacterium leprae directly from clinical specimens of leprosy patients Institute of Tropical Medicine
Real-Time PCR-High Resolution Melting (qPCR-HRM) analysis has been recently described for rapid drug susceptibility testing (DST) of Mycobacterium leprae. The purpose of the current study was to further evaluate the validity, reliability, and accuracy of this assay for M. leprae DST in clinical specimens.
The specificity and sensitivity for determining the presence and susceptibility ...