The interplay of psychological stress, increased intestinal permeability and low grade inflammation in the pathophysiology of functional and inflammatory gastrointestinal disorders. KU Leuven
In this project we will investigate whether similar abnormalities are present in the colon, which is of importance to study IBS, and whether the observed pathology also leads to hypersensitivity of the gut. In the second part of the project we will set up a treatment study with the antiinflammatory agent budesonide, first in the BB-rat and later also in patients with functional dyspepsia. From these results we will learn if inflammation is ...