Publications
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Lung Functioning and Inflammation in a Mouse Model of Systemic Juvenile Idiopathic Arthritis KU Leuven
Systemic juvenile idiopathic arthritis (sJIA) is an immune disorder characterized by fever, skin rash, arthritis and splenomegaly. Recently, increasing number of sJIA patients were reported having lung disease. Here, we explored lung abnormalities in a mouse model for sJIA relying on injection of IFN-γ deficient (IFN-γ KO) mice with complete Freund's adjuvant (CFA). Monitoring of lung changes during development of sJIA using microcomputer ...
Adaptation of Mycobacterium tuberculosis to impaired host immunity in HIV-infected patients Institute of Tropical Medicine
Background. It is unknown whether immunosuppression influences the physiologic state of Mycobacterium tuberculosis in vivo. We evaluated the impact of host immunity by comparing M. tuberculosis and human gene transcription in sputum between human immunodeficiency virus (HIV)-infected and uninfected patients with tuberculosis.
Methods. We collected sputum specimens before treatment from Gambians and Ugandans with pulmonary ...
Metals and the respiratory tract. KU Leuven
The inhalation of metallic compounds may lead to a wide variety of respiratory diseases, depending on the nature and amount of the inhaled agent, the site of its deposition in the respiratory tract, its clearance versus persistence in the lung, and host factors. This chapter focuses on the potential adverse respiratory effects of metals inhaled in the workplace. Rather than enumerating the respiratory toxicity of individual metallic elements, ...
Ex vivo evaluation of granulomatous diseases KU Leuven
Sarcoidosis is a systemic disease of unknown etiology. It is a moderately frequent disease (annual incidence of 1 to 35 per 100,000 adults) characterized by the development of granulomas, mainly in the lung and lymph nodes. Although the etiology is unknown, there are strong indications that environmental exposures, mainly in the workplace, may be involved in causing or triggering the disease. Thus, sensitization to beryllium may lead to a ...
Multi-walled carbon nanotubes directly induce epithelial-mesenchymal transition in human bronchial epithelial cells via the TGF-β-mediated Akt/GSK-3β/SNAIL-1 signalling pathway KU Leuven
BACKGROUND: Multi-walled carbon nanotubes (MWCNT) are currently under intense toxicological investigation due to concern on their potential health effects. Current in vitro and in vivo data indicate that MWCNT exposure is strongly associated with lung toxicity (inflammation, fibrosis, granuloma, cancer and airway injury) and their effects might be comparable to asbestos-induced carcinogenesis. Although fibrosis is a multi-origin disease, ...
The role of the innate immune system in the pathogenesis of systemic juvenile idiopathic arthritis: advances in understanding KU Leuven
Systemic juvenile idiopathic arthritis (sJIA) is a severe autoinflammatory childhood-onset immune disorder, classified as one of the JIA subtypes. Patients clinically present with fever, skin rash, enlarged lymph nodes (LNs), spleen and/or liver, and develop arthritis. Haematologically, neutrophilia (including immature neutrophils), leukocytosis, anaemia, and thrombocytosis is noticed. Patients have high plasma cytokine levels of interleukin-6 ...
LIKELIHOOD RATIO FOR PULMONARY SARCOIDOSIS AS A FUNCTION OF CD4/CD8 RATIO IN BRONCHOALVEOLAR LAVAGE FLUID Vrije Universiteit Brussel
BACKGROUND
Sarcoidosis is a chronic inflammatory disorder of unkown origin with most frequently affects the lungs. Noncaseating granulomas are the key pathologic finding which makes a bronchial biopsy obligatory to confirm the diagnosis of sarcoidosis. Since and elevated CD4/CD8 ratio of BALF lymphocytes is generally considered to suport the diagnosis of pulmonary sarcoidosis (PS), flowcytometric immunophenotyping of bronchoalveolar ...
Sarcoidosis is a chronic inflammatory disorder of unkown origin with most frequently affects the lungs. Noncaseating granulomas are the key pathologic finding which makes a bronchial biopsy obligatory to confirm the diagnosis of sarcoidosis. Since and elevated CD4/CD8 ratio of BALF lymphocytes is generally considered to suport the diagnosis of pulmonary sarcoidosis (PS), flowcytometric immunophenotyping of bronchoalveolar ...
Occupational exposure and respiratory diseases KU Leuven
During the 20th century coal workers' pneumoconiosis—or anthraco-silicosis—and asbestos-related diseases were the major occupational respiratory diseases among Belgian workers, both in terms of public health impact as well as public visibility. Except for asbestos-induced mesothelioma, the occurrence of these occupational diseases has been declining in recent decades, due to improved prevention but to a large extent also because many hazardous ...
Tissue is the issue University of Antwerp
Multimodal therapy, including preoperative chemoradiotherapy followed by total mesorectal excision, has become the standard treatment for patients with locoregionally advanced rectal cancer.1 We report on a 54- year old female patient with rectal adenocarcinoma cT3N0M0, who was treated with neoadjuvant chemoradiotherapy (capecitabine 825 mg/m² BID 5 days/week + 45 Gy in 25 fractions) followed by total mesorectal excision and adjuvant ...