Projects
Omics analysis in liquid biopsy samples of advanced tumours Ghent University
Analysis of plasma, platelets and urine nucleic acids: the value of liquid biopsy to improve diagnosis, follow-up and monitoring of treatment response of lung cancer and pancreatic cancer patients. University of Antwerp
Urine as a liquid biopsy for early stage cancer detection. University of Antwerp
A SIOPEN pragmatic clinical trial to MOnitor NeuroblastomA relapse with LIquid biopsy Sensitive Analysis Ghent University
High-risk neuroblastoma accounts for 15% of cancer related-deaths in children. Half of the >1500 patients yearly diagnosed with neuroblastoma in the EU have high-risk disease, which will relapse or progress in half these cases after first-line treatment. Relapsed neuroblastoma is aggressive and often therapy-resistant. Monitoring for disease relapse and therapy response is crucial for thesurvival chance of these patients. The current ...
Importance of a reliable diagnosis of myometrial lesions using ultrasonography and liquid biopsy biomarkers in clinical gynecological practice. KU Leuven
Malignant myometrial lesions (sarcomas) are highly aggressive and require radical surgery in an oncological centre. Benign myometrial lesions (myomas) may either be managed expectantly, treated medically or by selective uterine artery embolisation or surgically by laparoscopic myomectomy with morcellation. It is of utmost importance to accurately identify sarcomas, not only because any delay in diagnosis is associated with lower survival ...
Federated cloud-based Artificial Intelligence-driven platform for liquid biopsy analyses KU Leuven
Early prediction/detection of clinical response in metastatic NSCLC by improving liquid biopsy analysis KU Leuven
Non Small Cell Lung Cancer (NSCLC) patients are often treated with chemotherapy, which are toxic and can potentially lead to serious, even life-threatening side effects. Also, the quality of life can deteriorate. Unfortunately, not all patients respond to this treatment resulting in unnecessary treatment of these patients. Detecting the response at an early stage, preferably by a minimally or non-invasive alternative to tissue biopsies is ...
Liquid biopsy and HRD testing in ovarian cancer KU Leuven
To evaluate the performance of the Leuven Homologous Recombination Deficiency (HRD) assessment on non-tissue specimens, such as plasma and ascites, and compare its reliability in relation to the conventional HRD analysis conducted on tissue samples, specifically direct tumor biopsy. The successful validation of this non-invasive approach to HRD testing would allow the utilization of this method as a reliable alternative. Other applications of ...
Pan-cancer liquid biopsy screening for the identification of actionable RNA biomarkers Ghent University
The biggest challenges in cancer patient management are the use of more effective and less toxic treatmant modalities, better and less invasive methods to diagnose disease, to select the right drug, to monitor treatment response and to identify relapse disease early-on. Our project proposal aims to address several of these issures by the introduction of RNA based liquid biopsy guided precision oncology. We will screen easy-to-obtain plasma ...