Unravelling the cellular and molecular mechanisms underlying B-cell dysfunction during Leishmania donovani infections. Vrije Universiteit Brussel
Leishmania donovani is an intracellular protozoan parasite, transmitted to animals and humans by the bite of phlebotomine sandflies, which causes visceral leishmaniasis (VL). VL is characterized by the dissemination of parasites into the spleen, liver, lymph nodes and bone marrow, resulting in hepatosplenomegaly, fever and weight loss. It is estimated that every year 500 000 people worldwide develop VL and that 70 000 people succumb to the ...