Novel HIV inhibitors targeting the interaction between integrase and LEDGF/p75 KU Leuven
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A combination of nanoresolution microscopy techniques, such as atomic force microscopy (AFM) Fluorescence Imaging with One Nanometer Accuracy (FIONA) and tip enhanced Raman spectroscopy (TERS), will be used to study the biomolecular interactions of ligands with DNA and the impact of this interaction on the DNA structure. At first the binding of lens epithelium derived growth factor (LEDGF/p75) with chromatine will be studied. The information ...
The replication cycle of HIV is a complicated interplay between viral and cellular proteins. Until now antiretroviral therapy mainly targets the viral proteins although the interaction between the viral and cellular proteins could be interesting new drug targets. This strategy is mainly of interest because cellular proteins are much less prone to mutations which gives the virus less opportunity to develop drug resistance. My laboratory has ...
From a systems biology approach, mammalian viruses offer a unique starting point to study the complex biology of the human cell (1). Our group employs the replication of the human immunodeficiency virus type 1 (HIV-1) in cells to unravel the biology of nuclear import and integration (2). Central is the idea that retroviruses employ cellular proteins as cofactors to achieve important steps in replication. Since identified cofactors as ...