Publications
Androgen receptor knockout and knock-in mouse models KU Leuven
A novel human tau knock-in mouse model reveals interaction of Abeta and human tau under progressing cerebral amyloidosis in 5xFAD mice KU Leuven
Neural oscillations during cognitive processes in an App knock-in mouse model of Alzheimer's disease pathology KU Leuven
CMT2Q-causing mutation in the Dhtkd1 gene lead to sensory defects, mitochondrial accumulation and altered metabolism in a knock-in mouse model. Flanders Institute for Biotechnology KU Leuven
Contribution of GABAergic interneurons to amyloid-ß plaque pathology in an APP knock-in mouse model. Flanders Institute for Biotechnology KU Leuven
The role of receptor dimerization in androgen action: uncovering its physiological relevance using knockin mouse models KU Leuven
Efficacy and Imaging-Enabled Pharmacodynamic Profiling of KRAS G12C Inhibitors in Xenograft and Genetically Engineered Mouse Models of Cancer Vrije Universiteit Brussel
KRAS is one of the most commonly mutated oncogenes in lung, colorectal, and pancreatic cancers. Recent clinical trials directly targeting KRAS G12C presented encouraging results for a large population of non-small cell lung cancer (NSCLC), but resistance to treatment is a concern. Continued exploration of new inhibitors and preclinical models is needed to address resistance mechanisms and improve duration of patient responses. To further ...
Conditional mouse models support the role of SLC39A14 (ZIP14) in Hyperostosis Cranialis Interna and in bone homeostasis University of Antwerp
Neuroanatomical characterization of the Nmu-Cre knock-in mice reveals an interconnected network of unique neuropeptidergic cells Vrije Universiteit Brussel KU Leuven University of Antwerp
Neuromedin U (NMU) is an evolutionary conserved neuropeptide that has been implicated in multiple processes, such as circadian regulation, energy homeostasis, reward processing and stress coping. Although the central expression of NMU has been addressed previously, the lack of specific and sensitive tools has prevented a comprehensive characterization of NMU-expressing neurons in the brain. We have generated a knock-in mouse model ...