Projects
Innovative diagnostic and therapeutic measures to improve MDR-TB diagnosis and management in Conakry, Guinea Institute of Tropical Medicine
Autosomal Dominant Polycystic Kidney Disease: From bedside to bench and back KU Leuven
Unraveling the regulation of serine biosynthesis in breast cancer cells. KU Leuven
Breast cancer is the most frequent type of tumor among women worldwide, accounting for 24.2% of all the tumor cases. Due to these tremendous incidences, breast cancer is also the type of tumor causing the highest number of deaths, indeed around 600.000 women die every year because of this disease. By taking a closer look at the prognosis of patients diagnosed with breast cancer, it appears evident that the progression of the disease towards a ...
Overcoming resistance to mTOR inhibition in pancreatic neuroendocrine tumors: an analysis of the PI3K-Akt-mTORpathway beyond rapalogs. University of Antwerp
Towards the development of potent and selective inhibitors of hepatitis E virus. KU Leuven
Hepatitis A and E virus are the most prominent causes of acute viral hepatitis worldwide (chapter 1). Despite the availability of an effective vaccine for hepatitis A virus (HAV), it is widespread in developing countries and outbreaks still occur regularly in industrialized regions. Although most infections are asymptomatic, or have a mild clinical course, severe cases of hepatitis A may occur, especially in the elderly. The availability of ...
Prevention of glucose toxicity prevents renal damage during critical illness: mechanistic studies in a rabbit model. KU Leuven
Sugar Regulation of Nodulation: positioning the role of master sugar regulators during nodulation in soybean Ghent University
Sugar regulators integrate the plant’s sugar status into endogenous signaling pathways to coordinate developmental decisions. Three major conserved regulators TARGOT OF RAPAMYCIN (TOR), SNF1-RELATED PROTEIN KINASE1 (SnRK1), and HEXOKINASE1 (HXK1), have been extensively studied for their role in plant growth. But despite the fact that sugars are pivotal as energy for beneficial plant-associated microbes, such as rhizobia during nodulation, the ...
OOCARE: Caring for the oocyte under maternal metabolic stress by targeting the mitochondria. University of Antwerp
Translation regulation by TOR under limiting nutrient conditions Ghent University
Plants are subjected to a range of abiotic stresses and need to adjust their metabolic program accordingly for survival. The evolutionarily conserved target of rapamycin (TOR) plays a pivotal role in transducing beneficial input signals such as light, hormones and nutrients, towards growth promoting cellular processes. Reported upstream regulators and downstream effectors show that TOR supports plant growth through protein synthesis, but the ...