Projects
Study on the role of beta cell serotonin during pregnancy in the mouse. KU Leuven
Pregnancy is period in which the maternal body has to undergo several adaptations to meet the
demands of the fetus, for example in pancreatic beta cells. Pregnancy hormones stimulate prolactin
receptors (PRLRs) on beta cells to increase their capacity to produce insulin. In the last years, several
studies have been conducted on these changes in beta cells. Pancreatic islets of non-pregnant and
pregnant mice (at ...
Unrafeling the role of autophagy in cutaneous malignant melanoma. KU Leuven
Patrizia
14.00
In advanced cancer, autophagy, an evolutionary
conserved catabolic process, has been reported to support tumor progression.
Based on this premise,clinical trials have been initiated to evaluate the
possible benefitof the autophagy blocker chloroquine (CQ) for the treatment of
advanced cancers, with promising results. However, studies ...
The role of the DNA repair protein Apex1 in enteric nervous system development and function Hasselt University
The use of single cell RNA-sequencing to unravel which cell type is the main driver in the development of Biglycan-related thoracic aortic aneurysms. University of Antwerp
Unraveling the molecular mechanisms underlying cell cycle regulation in pre-implantation embryos. KU Leuven
The role of TET1 in the development and progression of prostate cancer KU Leuven
Primary prostate cancer (PCa) is a very heterogeneous disease in terms of clinical outcome, making it very hard to correctly predict the progression and aggressiveness of a prostate tumor. Besides genetics, also epigenetic changes play a crucial role in the development and progression of prostate cancer.
Exome analysis showed that the TET1 enzyme was mutated or had a loss of copy numbers in our cohort of primary high risk prostate ...
Towards novel therapeutic strategies in ischemic stroke by targeting von Willebrand factor and promoting fibrinolysis KU Leuven
Ischemic stroke is worldwide the second most common cause of death and the leading cause of permanent disability. In order to improve therapeutic and prophylactic therapy, it is imperative to understand what causes ischemic stroke and how ischemic stroke brain damage progresses. Up until recently, little was known about the thrombi that cause ischemic stroke. Moreover, experimental and clinical data have demonstrated progression of ischemic ...