Charting 4D Functional Maps of the Evolving Melanoma Ecosystem. KU Leuven
Tumors are made up of millions of cancer cells that can exhibit a multitude of distinct phenotypic cell states. It has been suggested that a restricted number of these state(s) is fated to fuel tumor growth and/or drive the metastatic spreading of the disease. As a result, these specialized states have become the targets of intense drug discovery efforts. However, based on (our own) recent findings, indicating that cancer cells can reversibly ...