Correlation between (changes in) functional beta cell mass and islet autoantibodies in (pre)type 1 diabetes with or without immune intervention Vrije Universiteit Brussel
In preparation of innovative beta cell therapy trials the present application aspires to study these relationships longitudinally in recent-onset T1D patients with or without anti-CD3 treatment and in first-degree relatives stratified according to autoantibody-inferred risk. In relatives and patients I will investigate whether (changes in) autoantibody levels, number or specificity coincide with (changes in) beta cell function measured by ...