Modeling neurodevelopmental epilepsy syndromes: the example of mosaic deletion of PCDH19 and its influence on tangential migration of interneurons. KU Leuven
This project aims at elucidating a mechanism behind a genetic disorder, using the developing mouse brain as a study object. Brain function depends on the maintenance of a balance between excitatory and inhibitory signals, emanating from different neuron and interneuron populations, respectively. When this balance is disrupted, conditions like epilepsy, intellectual dysfunction and autism can occur. Cortical interneurons develop in the basal ...